The free lipids of a sample of Mycobacterium leprae were extracted by a procedure designed to produce separate non-polar and polar fractions. The composition of these lipids was analysed semi-quantitatively by five special thin-layer chromatographic systems covering the total range of mycobacterial lipid polarities. In order of increasing polarity, the major lipids were dimycocerosates of phthi...

PURPOSE The aim of the present study was to investigate the immune response induced by Mycobacterium marinum infection in vitro and the potential of M. marinum as an immunotherapy for M. tuberculosis infection. METHODS The potential human immune response to certain bacillus infections was investigated in an immune cell-bacillus coculture system in vitro. As a potential novel immunotherapy, M....

INTRODUCTION Mycobacterium marinum causes skin and soft tissue, bone and joint, and rare disseminated infections. In this study, we aimed to investigate the relationship between treatment outcome and antimicrobial susceptibility patterns. A total of 27 patients with M. marinum infections were enrolled. METHODS Data on clinical characteristics and therapeutic methods were collected and analyze...

The in vitro susceptibilities of 16 Mycobacterium marinum strains to eight antimicrobial agents were determined by the agar dilution technique. The most active drugs were amikacin and kanamycin. Tetracycline, doxycycline, and minocycline were inhibitory, predominantly at concentrations slightly below the expected blood and tissue levels. Trimethoprim-sulfamethoxazole and erythromycin demonstrat...

A case of Mycobacterium Marinum infection of the nasal cavity is described. A 57 years old man was being on Infliximab for 2 years for severe psoriasis presented with five months history of epistaxis, nasal blockage and snoring. Local examination revealed bilateral nasal mass. The diagnosis of mycobacterial infection was suspected based upon the histopathological finding of granuloma in the bio...

Mycobacterium marinum is a photochromogenic myco bacterium capable of indu c in g a se lflimitin g loca li zed infection within the mouse foot pad ( 1.4 ). Because this infection is íwalogous to the M. leprae infection in the mouse, it has been suggested as an a lternative experimenta l model for studying the role of host immunity to M. leprae infection in the mouse foot pad (1 2. 16. 19). Pres...

Opportunist acid-fast bacilli sometimes cause progressive indolent infections of the skin, producing nodules, granulomatous lesions, abscesses, or ulcers. Some of these mycobacteria prefer temperatures lower than 370C for growth, and minor trauma or devitalized tissue probably aid their entry and establishment. One such organism, Mycobacterium marinum (balnei), was identified as the cause of ep...

Transcriptome analysis has played an essential role for revealing gene expression and the complexity of regulations at transcriptional level. RNA-seq is a powerful tool for transcriptome profiling, which uses deep-sequencing technologies to directly determine the cDNA sequence. Here, we utilized RNA-seq to explore the transcriptome of Mycobacteriummarinum (M. marinum), which is a useful model t...