To determine whether mycoplasma infection produces airway hyper-responsiveness to tachykinins and bradykinin and, if so, to elucidate the role of neutral endopeptidase (NEP), isolated hamster tracheal segments were studied under isometric conditions in vitro. Nasal inoculation with Mycoplasma pneumoniae potentiated contractile responses to neurokinin A and bradykinin, causing a leftward shift o...

1. Ramesh E, Raghunathan R, Manian RD et al. Synthesis and antibacterial property of quinolines with potent DNA gyrase activity. Bioorg Med Chem 2009; 17: 660–6. 2. Waites KB, Taylor-Robinson D. Mycoplasma and Ureaplasma. In: Murray PR, ed. Manual of Clinical Microbiology. Washington, DC: ASM Press, 2007; 1004–20. 3. Morozumi MS, Iwata K, Hasegawa K et al. Increased macrolide resistance of Myco...

Mycoplasma pneumoniae is a major cause of respiratory infections and a possible etiology of acute hepatitis. Acute hepatitis due to M. pneumoniae infection is often combined with presentation of pneumonia, even without lung involvement. The presentations and etiologies of M. pneumoniae-associated hepatitis with simultaneous, delayed, or without, lung involvement are different, and should be dis...

Mycoplasma pneumoniae cells are not phagocytized by peritoneal macrophages without opsonization. They are taken up after treatment with complement or antibody.

Eight species representative of the serological diversity of the Mycoplasmatales were tested for their ability to incorporate radiolabeled nucleic acid precursors into acid-insoluble material. Cultures in complex growth medium were centrifuged and resuspended in minimal essential medium (Eagle). For Acholeplasma laidlawii, labeling occurred mainly during the first 4 h of incubation, with substr...

We examined the blood of 48 patients from central and southern California diagnosed with autistic spectrum disorders (ASD) by using forensic polymerase chain reaction and found that a large subset (28/48 or 58.3%) of patients showed evidence of Mycoplasma spp. infections compared with two of 45 (4.7%) age-matched control subjects (odds ratio = 13.8, P < 0.001). Because ASD patients have a high ...

OBJECTIVE To ascertain the causative organisms of community acquired pneumonia (CAP) in Jordanian patients requiring hospital admission. METHODS A prospective study of both adults and children admitted to Princess Basma and Princess Rahma Teaching Hospitals in Irbid, Jordan with a diagnosis of CAP over a 6-month period from April to October 2002. RESULTS A total of 35 adult patients were ad...

Extrapulmonary manifestations of Mycoplasma pneumoniae pneumonia are uncommon and include hematologic, gastrointestinal, musculoskeletal, dermatologic, and neurologic complications. We report a case of serologically-confirmed M. pneumoniae infection complicated by severe neutropenia, thrombocytopenia, and hepatitis. The presence of antiplatelet and antineutrophil antibodies suggested that these...

Parkinsonism caused by infection is uncommon in children. We report 2 previously healthy children with acute self-limiting parkinsonism following Mycoplasma pneumoniae infection, with normal brain magnetic resonance imaging (MRI). Our case report expands the phenotype of parkinsonism associated with M. pneumoniae infection. We recommend that children with acute parkinsonism preceded by a period...

In January 2012, the European Centre for Disease Prevention and Control (ECDC) conducted an email based survey of European Union and European Economic Area countries to describe the existing surveillance activities for Mycoplasma pneumoniae infections, recent findings and existence of clinical guidelines for the treatment of M. pneumoniae infection. Of the 20 countries that participated in the ...