BACKGROUND Doxorubicin is a chemotherapeutic agent used in a wide spectrum of cancers. However, cardiotoxic effects have limited its clinical use. The early detection of doxorubicin-induced cardiotoxicity is crucial. The purpose of our study was to assess values of Doppler and tissue Doppler imaging (TDI)-derived myocardial performance index (MPI) in adult cancer patients receiving doxorubicin ...

OBJECTIVE To test the hypothesis that, in the initial evaluation of patients with suspected coronary artery disease (CAD), stress myocardial perfusion imaging (MPI) would result in less downstream testing than coronary computed tomographic angiography (CCTA). METHODS In this international, randomized trial, mildly symptomatic patients with an intermediate likelihood of having CAD, and asympto...

Introduction: The main purpose of this study was to compare transient ischemic dilation (TID) ratios in SPECT-low dose CT and SPECT Myocardial Perfusion Imaging (MPI) by application of different quantitative programs and quantify the possible shift in the upper normal limits of TID ratio in the SPECT-CT MPI. Methods: 149 Patients with low pre-test probability for coronary artery disease (CAD), ...

doppler-derived myocardial performance index (mpi), defined as the sum of isovolumetric contraction and relaxation durations divided by ejection time, is an easily measured and reproducible index that shows both systolic and diastolic myocardial function. the goal of this study was to define normal values of right ventricular (rv) mpi in neonates in the first 48 to 72 hours of life. fifty-one q...

The recent publication by Shaw, et al, (1) regarding the present status and future prospects for myocardial perfusion imaging (MPI) fails to explore one of the most important facts essential to understanding this issue and this commentary fails to fully address the fundamental inadequacy of MPI as a first line diagnostic screening tool for CAD. Figure 2 of this article clearly presents the spec...

Background: The implications of cardiac risk stratification before orthotopic liver transplantation (OLT) are not well established. We studied the usefulness of myocardial perfusion imaging (MPI) in this scenario. Methods: MPI data of 24 patients (9 females), candidates of OLT, were collected. They underwent MPI as part of their preoperative risk assessment. MPIs were interpreted by 2 nuclear p...

w Myocardial perfusion imaging (MPI) in acute myocardial infarction (MI) has had its ups and downs over the past 4 decades (1). “Cold-spot” imaging with thallium-201, technetium-99m tetrofosmin and sestamibi, wall motion assessment with gated radionuclide angiography, and “hot-spot” imaging with radionuclide-bound pyrophosphate, glucarate, antimyosin, annexin V (2), and more recently, duramycin...

BACKGROUND Little is known about soft tissue attenuation artifacts when an upright patient-position SPECTmyocardial perfusion imaging (MPI) system is used. In this investigation we sought to describe the patterns and frequency of attenuation artifacts associated with this type of instruments and we explored the impact of gender and body habitus on these artifacts. METHODS In a cross-sectional...

We contribute to the mathematical modeling and analysis of magnetic particle imaging which is a promising new in-vivo imaging modality. Concerning modeling, we develop a structured decomposition of the imaging process and extract its core part which we reveal to be common to all previous contributions in this context. The central contribution of this paper is the development of reconstruction f...

BACKGROUND Long-term intensive training leads to morphological and mechanical changes in the heart generally known as "athlete's heart". Previous studies have suggested that the diastolic and systolic function of the ventricles is unaltered in athletes compared to sedentary. The purpose of this study was to investigate myocardial performance index (MPI) by pulsed wave Doppler (PWD) and by tissu...