N(6)-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N(6)-hydroxymethyladenosine (hm(6)A) and N(6)-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe(II)- and α-ketoglutarate-dependent fat mass and obesity-associated (FTO) protein oxidize ...

FoxY is a member of the forkhead transcription factor family that appeared enriched in the presumptive germ line of sea urchins (Ransick et al. Dev Biol 2002;246:132). Here, we test the hypothesis that FoxY is involved in germ line determination in this animal. We found two splice forms of FoxY that share the same DNA-binding domain, but vary in the carboxy-terminal trans-activation/repression ...

Advanced glycation endproducts (AGEs) in food products may pose health risks, and thermal processing of foods accelerates the formation of AGEs. The effects of heat treatments (65-100 °C, 0-60 min) on the formation of AGEs including N(ε)-carboxymethyllysine (CML) and N(ε)-carboxyethyllysine (CEL) in ground beef were investigated. The levels of CML and CEL in ground beef steadily increased with ...

Indirect development, in which embryogenesis gives rise to a larval form, requires that some cells retain developmental potency until they contribute to the different tissues in the adult, including the germ line, in a later, post-embryonic phase. In sea urchins, the coelomic pouches are the major contributor to the adult, but how coelomic pouch cells (CPCs) are specified during embryogenesis i...

Bu ara?t?rman?n amac? 2019 Türkçe Dersi Ö?retim Program? 6. s?n?f kazan?mlar?n? belirli ölçütlere göre de?erlendirmektir. Ara?t?rmada genel tarama modellerinden kesitsel tikel modeli kullan?lm??t?r. Ara?t?rman?n çal??ma grubunu 2020-2021 ö?retim y?l?nda Türkiye’nin 12 farkl? bölgesinde çe?itli üniversitelerdeki e?itimi ana bilim dal?nda görev yapmakta olan 35 üyesi olu?turmaktad?r. Ara?t?rmadak...