Non-activated 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines were used as building blocks for the stereoselective synthesis of novel cis-2-cyanomethyl-4-phenylpiperidines via a microwave-assisted aziridine to piperidine ring expansion followed by a radical-induced nitrile translocation through initial formation and subsequent cleavage of intermediate bicyclic iminyl radicals. Furthermore, these 2...

Novel palladium-catalyzed reactions of arenediazonium tetrafluoroborates with N,N-diprotected allylamines are presented. The reaction of arenediazonium tetrafluoroborates with N,N-(Boc)(2) allylamine allows for an easy approach to cinnamylamines whereas using 2-alkynyl-N-(allyl)trifluoroacetanilides and 2-iodo-N-(allyl)trifluoroacetanilide the reaction provides a useful tool for appending indol...

Selenocyanates form an interesting class of organic selenium compounds as they serve as 21 multifunctional agents (being the precursors of seleninic acids and diselenides in synthetic 22 chemistry and as antimicrobial and cytotoxic agent in biology) and, due to their similarity with 23 better known thiocyanates promise high biological activity. Yet whilst selenocyanates are common 24 in synthet...

The production of fungal metabolites can be remarkably influenced by various cultivation parameters. To explore the biosynthetic potentials of the marine fungus, Neosartorya pseudofischeri, which was isolated from the inner tissue of starfish Acanthaster planci, glycerol-peptone-yeast extract (GlyPY) and glucose-peptone-yeast extract (GluPY) media were used to culture this fungus. When cultured...

indole is a nitrogen-containing heterocycle. it is a very important motif in agriculture and pharmacy. many compounds containing indole moiety has been isolated form nature. it is also an important part in natural alkaloids. tryptophan is an amino acid which posses indole. 3-sustituted indoles are the main group of its derivatives. because the wide-spread application of 3-substituted indolic co...

in this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes is described. the condensation of indoles with carbonyl compounds catalyzed by citric acid in water affords bis(indolyl)methanes in high yields and relatively short reaction times. the advantages of this method are using of water as a low cost solvent and efficient recyclability of the catalyst.

An axially chiral N,N′-bisindole is shown on the cover picture, representing one of fruits tree indole chemistry. In their Research Article (e202300419), Yu-Chen Zhang, Feng Shi, and co-workers describe organocatalytic enantioselective construction scaffold with promising applications in medicinal chemistry asymmetric catalysis. Aptamers Carbon Dioxide Capture Batteries Photocatalysis

2-Amino-9H-pyrido[2-3-b]indole (AαC) is a carcinogenic heterocyclic aromatic amine (HAA) formed during the combustion of tobacco. AαC undergoes bioactivation to form electrophilic Noxidized metabolites that react with DNA to form adducts, which can lead to mutations. Many genotoxicants and toxic electrophiles react with human serum albumin (albumin); however, the chemistry of reactivity of AαC ...

Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and one of leading causes associated death worldwide. This due to highly resistant nature this malignancy lack effective treatment options for advanced stage HCC patients. The hyperactivity PI3K/Akt Ras/Raf/MEK/ERK signaling pathways contribute progression, survival, motility, resistance mechanisms, interaction these two ...

In the presence of Rh(2)(OAc)(4) (OAc = acetate) and TBA(2)WO(4) (TBA = tetra-n-butylammonium), the N-silylation of indole derivatives with hydrosilanes efficiently proceeded to give the corresponding N-silylated indoles in high yields. Pyrrole and carbazole were also N-silylated with the combined catalysts.