Sean D. Taylor, Jesse J. Salk and Jason H. Bielas Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109, USA Department of Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195, USA Department of Pathology, University of Washington Medical Center, 1959 NE Pacific St, Seattl...

D. B. Percival, Applied Physics Laboratory, University of Washington, Box 355640, Seattle, WA 98195–5640, USA. ([email protected]) D. A. Rothrock, Applied Physics Laboratory, University of Washington, Box 355640, Seattle, WA 98195–5640, USA. ([email protected]) A. S. Thorndike, Department of Physics, University of Puget Sound, 1500 N. Warner, Tacoma, WA 98416, USA. (thorndike@ups...

Withaferin A (WA), a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera, inhibits growth of MDA-MB-231 and MCF-7 human breast cancer cells in culture and MDA-MB-231 xenografts in vivo in association with apoptosis induction, but the mechanism of cell death is not fully understood. We now demonstrate, for the first time, that WA-induced apoptosis is mediated by reac...

Professor Terrance J. Quinn II, Principal Investigator SFOS, University of Alaska Fairbanks, Juneau AK (Phone: 907-796-5457, Email: [email protected]) Ms. Haixue Shen, PhD Graduate Student SFOS, University of Alaska Fairbanks, Juneau AK Dr. Martin Dorn, Co-Investigator Alaska Fisheries Science Center, Seattle WA Dr. James Ianelli, cooperator Alaska Fisheries Science Center, Seattle WA Mr. Ste...

The walls of Aspergillus nidulans conidia contain a green pigment that protects the spores from damage by ultraviolet light. At least two genes, wA and yA, are required for pigment synthesis: yA mutants produce yellow spores, wA mutants produce white spores, and wA mutations are epistatic to yA mutations. We cloned wA by genetic complementation of the wA3 mutation with a cosmid library containi...

We describe examples of wA gene inactivation (resulting in white conidiospores) obtained during transformation of Aspergillus nidulans. One wA- transformant was obtained by transformation with a prn+ plasmid of a strain with green conidia (wA+) which was unable to catabolize L-proline (prn-). This transformant contains a very large number of plasmid copies integrated at a single site inseparabl...

The purpose of this study was to examine the regulation of prosurvival factors heat shock factor 1 (HSF1) and breast cancer susceptibility gene 1 (BRCA1) by a natural withanolide withaferin A (WA) in triple negative breast cancer cell lines MDA-MB-231 and BT20. Western analysis was used to examine alternations in HSF1 and BRCA1 protein levels following WA treatment. A protein synthesis inhibito...

BACKGROUND The concept of work ability (WA) has a 30-year history in Finland, where it has been used extensively in occupational health (OH) research and practice. The extent to which WA has been integrated into UK OH practice is unclear. AIMS (i) To compare knowledge, understanding and use of WA among OH nurses and physicians in the UK and Finland and (ii) to identify factors that influence ...