PURPOSE To determine the relationship between peripapillary retinal nerve fiber layer (PRNFL) swelling and eventual PRNFL atrophy, and between PRNFL swelling/atrophy and neural function, in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy (pNAION). METHODS pNAION was induced in five normal, adult male rhesus monkeys by laser activation of intravenously injected rose...

Obstructive sleep apnea hypopnea syndrome; Ocular complications Abstract Introduction: Sleep disorders are common and obstructive sleep apnea hypopnea syndrome (OSAHS) is the commonest. OSAHS is not commonly diagnosed by the ophthalmologist, but it has many systemic and ocular complications. Aim of the work: The aim of this study was to detect the effect of sleep related breathing disorders on ...

BACKGROUND In patients with bilateral sequential nonarteritic anterior ischemic optic neuropathy (NA-AION), previous studies have reported conflicting results on whether or not the visual outcome is similar in the 2 eyes. The authors investigated this issue in 174 consecutive patients with bilateral NA-AION. METHODS At the first visit, all patients had a detailed ophthalmic and medical histor...

OBJECTIVE To refine the criteria for the diagnosis of amiodarone-related optic neuropathy by including a broader spectrum of clinical features, thus helping to differentiate this entity from nonarteritic anterior ischemic optic neuropathy coincidentally affecting a patient taking amiodarone. METHODS A retrospective case review of 22 patients who developed optic neuropathy while taking amiodar...

Nowadays there is no unique and well-established treatment for nonarteritic anterior ischemic optic neuropathy, despite being the main acute pathology that affects the optic nerve in the elderly population and often resulting in a significant loss of visual acuity. The effectiveness of oral steroids is still under debate in the international literature, although many studies show that patients ...

OBJECTIVE To describe visual acuity outcomes of patients in the Ischemic Optic Neuropathy Decompression Trial (IONDT) after 24 months of follow-up. DESIGN The IONDT is a single-masked, multicenter, randomized clinical trial. SETTINGS Patients were evaluated and followed up at 25 clinical centers located throughout the United States. Data were sent to and analyzed at a central coordinating c...

Purpose To report a case of a temporal artery biopsy negative anterior ischemic optic neuropathy associated with a recently completed course of pegylated interferon 2 α with ribavirin for chronic hepatitis C. Observations Despite the early presentation with symptoms and prompt treatment with systemic intravenous steroids the patient experienced deterioration of their optic neuropathy over the...

Advances in cystic fibrosis management have significantly improved life expectancy in these patients. However, we are now faced with a growing number of long-term extrapulmonary consequences of this disease, including ophthalmic complications of diabetes in cystic fibrosis patients. We present a unique report that documents a case of diabetic papillopathy progressing to nonarteritic anterior is...