Background Implementation of additional targeted vaccinations to prevent infectious diseases in the older adults is under discussion in different countries. When considering the added value of such preventive measures, insight into the current disease burden will assist in prioritization. The aim of this study was derive the first estimates of the disease burden in adults aged 50 years or over ...

Coastal forests along the southeastern Gulf of Mexico are known to be diminishing at an alarming rate. The live-oak dominant chenier southeast Louisiana amongst those exhibiting steepest declines. remnant stands have experienced numerous hurricanes and intense storm events in recent years, calling into question current status immediate future this imperiled natural resource. Despite their noted...

As the world’s urban population increases to predicted 70% of total population, infrastructure and built-up land will continue grow as well. This growth have an impact on heat island effect in all cities. The tree canopy has been found be one few factors that can lessen effects effect. study seeks accomplish two objectives: first, we examine use a commonly used machine learning classifier (e.g....

The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins. They have been implicated in a host of inflammatory disorders. Recent developments have greatly enhanced our understanding of the molecular mechanisms by which different inflammasomes are a...

Little is known about innate immunity and components of inflammasomes in airway epithelium. This study evaluated immunohistological evidence for NLRP3 inflammasomes in normal and inflamed murine (Balb/c) airway epithelium in a model of ovalbumin (OVA) induced allergic airway inflammation. The airway epithelium of control mice exhibited strong cytoplasmic staining for total caspase-1, ASC, and N...

In this issue of Ceil, we take the unusual step of publishing two articles each of which reports the identification of a different gene in the appropriate chromosomal region associated with the human disease of spinal muscular atrophy (SMA). Each paper individually meets the standard for publication in providing adequate evidence to identify systematic changes in the gene in patients with the d...

BACKGROUND Bladder cancer (BCa) is the ninth most common form of cancer in the world. There is a continuing need not only for improving the accuracy of diagnostic markers but also for the development of new treatment strategies. Recent studies have shown that the renin-angiotensin system (RAS), which include the angiotensin type 1 (AT1R), type 2(AT2R), and Mas receptors, play an important role ...

Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of EBOV hemorrhagic fever. In the present study, 21 cynomolgus monkeys were experimentally infected with EBOV and examined sequentially over a 6-day period to investigate the pathological events of EBOV...