BACKGROUND/AIM Only 0.1-0.17% of all lung cancer patients are diagnosed with stage I or II small cell lung cancer (SCLC). Radiochemotherapy remains the standard treatment for limited stage disease. This study focused on prognostic factors in early stage SCLC treated with radiochemotherapy. PATIENTS AND METHODS Seven factors in eight patients with early stage SCLC were analyzed concerning the ...

Golgi stacks were previously shown to be converted into tubular networks when incubated in mitotic cytosol depleted of the coatomer subunit of COP I coats (Misteli and Warren, 1994). Similar, though smaller, networks are now shown to be an early intermediate on the Golgi fragmentation pathway both in vitro and in vivo. Their appearance mirrors the disappearance of Golgi cisternae and at their p...

Bub1 (for budding uninhibited by benzimidazole 1), one of the main spindle checkpoint kinases, acts as a kinetochore scaffold for assembling other checkpoint proteins. Here, we identify a plant Bub1-related kinase 1 (BRK1) in rice (Oryza sativa). The brk1 mutants are sterile due to the precocious separation of sister chromatids at the onset of anaphase I. The centromeric recruitment of SHUGOSHI...

What turned you on to biology in the first place? I’ve always been interested in biology. I grew up in the Sonora Desert outside Tucson, Arizona. I was a budding pre-teen naturalist catching snakes, lizards and tarantulas to sell to collectors. I hunted everything from horned toads to birds and jackrabbits, and I had every imaginable pet, including a very large frog (grandpa), a squirrel (chipp...

ing proteins assembles at the site marked by the cue, *Department of Molecular and Cell Biology then a polarized actin and septin cytoskeleton assemUniversity of California, Berkeley bles, and the secretory apparatus becomes oriented Berkeley, California 94720 toward the spatial cue. Considerable information about †Department of Molecular and Cellular Physiology bud formation has been obtained ...

Erythropoietin (EPO) has been proposed as a novel cytoprotectant in ischemia-reperfusion (I/R) injury of the brain, heart, and kidney. However, whether EPO exerts its protection by prevention of postischemic microcirculatory deterioration is unknown. We have investigated the effect of EPO on I/R-induced microcirculatory dysfunctions. We used the mouse dorsal skinfold chamber preparation to stud...