Nano-solidified intermedias (NSI) of cisplatin were prepared via biomineralization and applied to reverse the drug resistance of cancers in vitro and in vivo by an alternative internalization pathway.

Melanoma is the most aggressive form of skin cancer and various treatments have been investigated to treat this disease, but drug resistance remains an important factor in failure conventional therapeutics. Here we describe development, optimisation characterisation alginate, chitosan, pullulan, their combined nano-emulsions as delivery platforms for potential application melanoma. A novel nano...

Background: Eptifibatide (Integrilin) is an intravenous (IV) peptide drug that selectively inhibits ligand binding to the platelet GP IIb/IIIa receptor. It is an efficient peptide drug, however has a short half-life. Therefore, antithrombotic agents like eptifibatide are required to become improved with a protected and targeted delivery system such as using nano-liposomes to the site of thrombu...

Drug developers recruit and combine principles, procedures and strategies from chemistry, pharmacology, nanotechnology and biotechnology, focusing on the generation of functional vehicles as nano-carriers of drugs for improved stability and enhanced intracellular delivery.[...].

Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. C...

Silver sulfadiazine is used to prevent and treat infections of second- and third-degree burns. It kills a wide variety of bacteria. In this study silver sulfadiazine was used in gelatin based electro-spun nano-fibers with various drug to polymer ratios (0, 5, 10, 15 and 20 %). SEM, EDX and FTIR analysis showed that the continuous, bead-free, fine fibers containing silver sulfadiazine as an anti...

Drug Delivery In article number 2000069, Boaz Mizrahi and co-workers report a new nano delivery system that is based on injectable liquid copolymer. The copolymer, starPEG-PLGA (red blue in the image) mixed with drug (green spheres without any solvents or excipients. After mixture injected into body, copolymer self-assembles situ well-defined nanoparticles.

Many bioactive natural products are derived from traditional Chinese medicine. Some of them showed good treatment potential in tumor chemotherapy. However, limited by the poorly solubility and non-selective toxicity most products, their antitumor efficacy could not be further applied clinicals. Nano-drug delivery systems provided platforms for treatment, many microenvironment-responsive nano-de...

BACKGROUND Nanomedicine is the medical application of nanomaterials that may have an infinite size with the range less than 100 nm. This science has provided solutions to many of the current limitations in the diagnosis and treatment of diseases. Therefore, the pharmacist's knowledge and awareness of nano-pharmaceutical drugs will increase their availability in the market, and will improve the ...