Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system - liposome-encapsulated acetate nanop...

Heterogeneous catalysis is of paramount importance in chemistry and energy applications. Catalysts that couple light energy into chemical reactions in a directed, orbital-specific manner would greatly reduce the energy input requirements of chemical transformations, revolutionizing catalysis-driven chemistry. Here we report the room temperature dissociation of H(2) on gold nanoparticles using v...

Magnetic nanoparticle-mediated intracellular hyperthermia has been a largely experimental modality of hyperthermia, but this treatment modality has the potential to achieve tumor targeted heating without any side effects. The technique consists of targeting magnetic nanoparticles to tumor tissue and then applying an external alternating magnetic field to induce heat generation by the magnetic n...

Development of synthesis protocols for realizing nanomaterials over a range of sizes, shapes and chemical compositions is an important aspect of nanotechnology. A number of recipes have been developed for the synthesis of metal nanoparticles in polar (for example, water) and non-polar organic solvents, each method accompanied by characteristic advantages and disadvantages. Specific applications...

Nanofibers are one-dimensional nanomaterial in fiber form with diameter less than 1 µm and an aspect ratio (length/diameter) larger than 100:1. Among the different types of nanoparticle-loaded nanofiber systems, nanofibers loaded with magnetic nanoparticles have gained much attention from biomedical scientists due to a synergistic effect obtained from the unique properties of both the nanofiber...

Gold nanoparticles (Au NPs) have attracted much attention due to their potential applications in nano-medicine. While numerous studies have quantified biomolecular adsorption to Au NPs in terms of equilibrium binding constants, far less is known about biomolecular orientation on nanoparticle surfaces. In this study, the binding of the protein α-synuclein to citrate and (16-mercaptohexadecyl) tr...

Nanoparticle alloys of platinum (Pt) and another metal are desirable for catalytic applications to decrease the loading of the precious metal and alter the physiochemical structure of these materials to enhance their catalytic properties. This study explores the potential of producing gold and platinum nanoparticle alloys using a microplasma reduction technique. In this process, metal salt prec...

Nanoparticles can self-assemble into highly ordered twoand three-dimensional superlattices. For many practical applications these assemblies need to be integrated into polymeric matrices to provide stability and function. By appropriate co-assembly of nanoparticles and polymers it has become possible to tailor the nanoparticle superlattice structure via the length and stiffness of the polymer c...

Strategies to achieve controlled nanoparticle aggregation have gained much interest, due to the versatility of such systems and their applications in materials science and medicine. In this article we demonstrate that coiled-coil peptide-induced aggregation based on electrostatic interactions is highly sensitive to the length of the peptide as well as the number of presented charges. The quater...

The collaboration between Sharp Laboratories of America (SLA), Oregon State University (OSU) and ORNL focused on low thermal budget pulse thermal processing (PTP) technique to develop high performance copper zinc tin sulfide (CZTS) thin film system for advanced photovoltaic (PV) applications, with the goal to develop novel fabrication processes for the manufacture of low-cost, high-performance ...