One vital responsibility of all law enforcement officers lies in their obligation to defend themselves and those around them in the event of a violent threat. The best tool available to them to perform this duty is their sidearm and their skill in using it. To evaluate the efficiency of this tool use, seventy-one police officers participated in a field study examining the relationship between w...

Physiological measures have increased in popularity due to the growing availability of equipment allowing their measurement in real-time. Eye blinks are an easy measure to collect using video capture. Our findings indicate that blink counts can differentiate between taskloads and task types during a computer based task, and reflect subjective workload ratings. Blink counts were significantly lo...

It has been proposed that allotypic trophoblast lymphocyte cross-reactive (TLX) antigens are involved in the maintenance of normal human reproduction. Despite such a potentially important role for TLX antigens, isolation of human TLX proteins has not yet been reported. As an initial step toward elucidation of the structure and function of TLX antigens, we have isolated TLX proteins from Lubrol-...

factor that is robustly expressed in progenitor cells of the ventricular and subventricular zones during neurogenesis. To investigate the role of tlx in neocortical development we generated a targeted deletion of tlx by homologous recombination. Here we compared the lamination, connectivity and patterning of cortical regions in adult tlx–/– mice and their wild-type littermates. We found first t...

The divergent homeobox-containing transcription factor, Tlx-3 (also known as Hox11L2/Rnx), is required for proper formation of first-order relay sensory neurons in the developing vertebrate brainstem. To date, however, the inductive signals and transcriptional regulatory cascade underlying their development are poorly understood. We previously isolated the chick Tlx-3 homologue and showed it is...

Neural stem cells (NSCs) continually produce new neurons in postnatal brains. However, the majority of these cells stay in a nondividing, inactive state. The molecular mechanism that is required for these cells to enter proliferation still remains largely unknown. Here, we show that nuclear receptor TLX (NR2E1) controls the activation status of postnatal NSCs in mice. Lineage tracing indicates ...