In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it comes to the delivery of pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms. Hence, ocular inserts were prepared with prolonged release o...

BACKGROUND Nasal valve collapse and especially internal nasal valve insufficiency is a common cause of nasal airway obstruction. This study compares the effects of spreader graft and overlapping lateral crural technique on rhinoplasty by rhinomanometry. METHODS Fifty patients were randomly assigned into two groups and underwent spreader graft or overlapping lateral crural technique. Objectiv...

introduction: spontaneous perforation of the nasal septum is an uncommon condition. nasal inhalation of substances such as cocaine has long been linked to this perforation. case report: this report describes the case of a 46-year-old woman who was addicted to methamphetamine and who presented with perforation of the nasal septum.this is the first reported case of nasal septal necrosis linked to...

We present a fast, reliable and inexpensive restriction-free cloning method for seamless DNA insertion into any plasmid without sequence limitation. Exponential megapriming PCR (EMP) cloning requires two consecutive PCR steps and can be carried out in one day. We show that EMP cloning has a higher efficiency than restriction-free (RF) cloning, especially for long inserts above 2.5 kb. EMP furth...

Background Plantar heel pain is one of the most common musculoskeletal conditions affecting the foot and it is commonly experienced by older adults. Contoured foot orthoses and some heel inserts have been found to be effective for plantar heel pain, however the mechanism by which they achieve their effects is largely unknown. The aim of this study was to investigate the effects of foot orthoses...

The present work deals with the results of the experimental investigations carried out on augmentation of turbulent flow heat transfer in a horizontal tube by the means of tube inserts, with air as working fluid. Experiments were carried out initially for the plain tube. Nusselt number and friction factor obtained experimentally were validated against those obtained from theoretical correlation...