Studies were performed in anesthetized control dogs (n = 6) and in dogs (n = 6) with acute low-output heart failure produced by inflation of a balloon in the thoracic inferior vena cava. Studies were designed to determine the effects of synthetic atrial natriuretic peptide on renal function and renin release in this acute high-renin, sodium-retaining preparation. Intrarenal infusion of syntheti...

OBJECTIVES This paper will describe associations between plasma natriuretic peptide levels and the severity and symptoms of mitral regurgitation (MR). BACKGROUND A biochemical test that assisted grading of the severity of MR and the interpretation of symptoms would be of clinical value. METHODS Forty-nine patients with isolated MR and left ventricular (LV) ejection fractions (EFs) of >55% u...

Background Natriuretic peptide receptors A (NPR-A) and B (NPR-B) are transmembrane guanylyl cyclases that regulate blood pressure, heart size and long bone growth. Unlike most cell surface receptors that are desensitized by direct phosphorylation, phosphorylation of natriuretic peptide receptors is essential for activation, and dephosphorylation causes their desensitization. While there are six...

B-type natriuretic peptide is a neurohormone secreted from the cardiac ventricles in response to ventricular stretch and pressure overload. It counteracts the vasoconstriction that occurs as a compensatory mechanism in heart failure. A new test for measuring plasma levels of B-type natriuretic peptide can help in the diagnosis and treatment of patients with congestive heart failure. Dyspnea ass...

1. Introduction smaller fragments some of which may also have biological activity [5]. Less is known about the procession of BNP; it In the 20 years which have passed since the first is believed to be more constitutively expressed. Pro-brain description by de Bold of a natriuretic and diuretic natriuretic peptide is a 108-amino acid peptide also cleaved substance produced in the heart [1], a la...

1. Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC: Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. ANESTHESIOLOGY 2009; 110:738–47 2. Fox AA, Shernan SK, Collard CD, Liu KY, Aranki SF, DeSantis SM, Jarolim P, Bod...

OBJECTIVES The present study was designed to compare the secretion patterns of two cardiac hormones--A-type (atrial) and B-type (brain) natriuretic peptides--from the ventricles in patients with old myocardial infarction. BACKGROUND Plasma levels of these two natriuretic peptides are increased, and their secretion from the ventricles is augmented, in patients with congestive heart failure. ...

BACKGROUND Dendroaspis natriuretic peptide (DNP) is the newest member of the natriuretic peptide family and is a circulating peptide in humans. The effects of DNP on the human vasculature are unknown. Since other natriuretic peptides are known to cause vasorelaxation, we determined the response to DNP on human blood vessels in vitro. We also investigated the mechanism of DNP mediated vasorelaxa...