Several reports suggest that antimicrobial resistance is an increasing global problem; but like most pandemics, the greatest toll is in the less developed countries. The dismally low rate of discovery of antimicrobials compared to the rate of development of antimicrobial resistance places humanity on a very dangerous precipice. Since antimicrobial resistance is part of an organism's natural sur...

NATURE | VOL 411 | 14 JUNE 2001 | www.nature.com 843 Collectively, plants produce a remarkably diverse array of over 100,000 low-molecular-mass natural products, also known as secondary metabolites. Secondary metabolites are distinct from the components of intermediary (primary) metabolism in that they are generally nonessential for the basic metabolic processes of the plant. Most are derived f...

The present study deals with the phytochemical investigation and therapeutic use importance of two plants Andrographis paniculata and Aloe vera. It is an important medicinal plant worldwide trend towards the utilization of natural plant remedies has created an enormous need for the use of medicinal plants. The methanol extract of same plants were subjected to analysis the antimicrobial activity...

Natural Antimicrobial peptides (AMPs) are important components of immune systems and possess immuno-modulatory and broad spectrum antimicrobial activities. These host-defense peptides failed to resist protease degradation or to efficiently inhibit biofilm formation. We describe in this review the different strategies to improve AMPs and develop peptides that could be used clinically and in indu...

A lactic acid bacterium presenting antimicrobial activity against a Lactobacillus acidophilus strain used for eradication of acid inhibition was isolated from a natural cheese. The 16S rRNA gene sequence of the isolate best matched with a strain of L. rhamnosus and was designated L. rhamnosus CJNU 0519. The antimicrobial activity of the partially purified bacteriocin of CJNU 0519 was abolished ...

Human beta-defensin 3 has received great interest for possible pharmaceutical applications. To characterize the biology of this antimicrobial peptide, the mouse beta-defensin 14 has been selected as a prototypical model. This report provides definite evidence of true orthology between these defensins and reveals molecular diversity of a mammalian specific domain responsible for their antimicrob...

The skin actively contributes to host defense by mounting an innate immune response that includes the production of antimicrobial peptides. These peptides, which include but are not limited to the cathelicidin and defensin gene families, provide rapid, broad-spectrum defense against infection by acting as natural antibiotics and by participating in host cell processes involved in immune defense...

introduction: in this study, the chemical composition and antimicrobial activity of essential oil of ziziphora clinopodiodes and its potential application as a natural preservative in reducing the indigenous microbial population of hamburger were investigated. method: essential oil of ziziphora clinopodiodes cultivated in iran was obtained by hydro-distillation method (hdm). chemical compositio...

Background: With considering the importance of natural products for their remedial and therapeutic value, this research was aimed to analyze the chemical compositions and antimicrobial activity of four propolis samples from different areas of Iran (Chenaran, Taleghan, Morad Beyg, and Kalaleh) with various climates and flora. Methods: Ethanolic (70% EtOH) and dichlromethane (DCM) extracts of Ira...

BACKGROUND The proliferation of antibiotic-resistant microorganisms, along with the lack of new drugs against them, has elicited the interest of the scientific community on the study and development of endogenous synthetic compounds with bacteriostatic or bactericidal activity. In recent years, several short-chain, low molecular weight peptides isolated from natural sources such as plants and a...