Correspondence: Francisco Alvarez-Lerma intensive Care Unit, Hospital del Mar, Passeig Marítim, 25-29, 08003, Barcelona, Spain Tel +34 93 248 3125 Fax +34 93 248 3254 email [email protected] Abstract: Doripenem (S-4661) is a new parenteral antibiotic from the carbapenem class; similarly to imipenem and meropenem, it has a broad-spectrum activity against Gram-positive, Gram-negative, and ana...

Doripenem (S-4661) is a new parenteral antibiotic from the carbapenem class; similarly to imipenem and meropenem, it has a broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria. It is active against multiresistant Gram-negative bacilli such as extended-spectrum beta-lactamase-producing (ESBL) Gram-negative Enterobacteriaceae and nonfermentative Gram-negative bacil...

Against most test strains of Gram-negative bacilli, the in vitro effect of FR-31564 together with beta-lactam antibiotics or trimethoprim was strongly synergistic; with tetracycline and nalidixic acid the effect was additive; and with gentamicin and sulfamethoxazole the effect was additive or antagonistic. FR-31564 was markedly synergistic with beta-lactam antibiotics against beta-lactam antibi...

Six strains of Gram-negative non-motile bacilli from cats have been described. They do not grow on ordinary media. They do grow, however, on a medium to which an autoclave-labile substance alone has been added as an accessory growth factor. These bacilli are similar to Bacillus parainfluenzaaeisolated from man. One strain of a Gram-negative non-motile bacillus more exacting than Bacillus influe...

The specific activity, substrate profile, response to inhibitors, inducibility, and cellular localization of the beta-lactamase produced by an ampicillin-resistant strain of Haemophilus influenzae type B were investigated. In these properties the enzyme resembles beta-lactamases produced by other gram-negative bacilli more closely than those produced by gram-positive organisms. It is quite simi...

In vitro evaluation of ceftazidime antimicrobial activity in infections caused by burn and its comparison to the other antibiotics is presented. In vitro tests for susceptibility to ceftazidime and other antibiotics were carried out on 744 bacterial strains collected from burn infections. The results have shown that generally ceftazidime was more active against Pseudomollas aeruginosa an...

INTRODUCTION Isolation of common pathogens involved in ocular infection, and their in-vitro susceptibility to commonly-used ocular antibiotics, as well as the trends in antibiotic resistance developed by these pathogens, were investigated. METHODS Corneal scrapings were obtained from 318 hospitalised patients and inoculated directly onto enriched and differential culture media. Subcultures we...

OBJECTIVE Gram negative bacilli are among the most important microbial agents involved in both hospital- and community-acquired infections. The quinolones are preferred antibacterial agents for the treatment of both community- and hospital-acquired urinary tract infections caused by gram negative bacilli because of their strong antibacterial effects, and because they can be administered both or...

background and objectives: patients at intensive-care-unit (icu) are at risk of acquiring nosocomial infections which contributes to higher rates. approximately 25% of all hospital infections and 90% of outbreaks occur in icus. multi-resistant gram-negative rods are important pathogens in icus, causing high rate of mortality. the purpose of this study was to investigate the antimicrobial resist...