Impaired DNA damage repair, especially deficient transcription-coupled nucleotide excision repair, leads to segmental progeroid syndromes in human patients as well as in rodent models. Furthermore, DNA double-strand break signalling has been pinpointed as a key inducer of cellular senescence. Several recent findings suggest that another DNA repair pathway, interstrand cross-link (ICL) repair, m...

conclusions approximately one quarter of premature neonates had early mortality, which can be predicted by low gestational age, low birth weight, low apgar score, need to intensive supports, postpartum complications, multiple gestation and history of maternal illnesses. objectives we aimed to determine mortality rate and its main indicators among premature neonates in our region with the aim of...

sareshtedari m 1 (md) , shahamat h 1 (md) , sadeghi t 2 * (msc)       1 department of pediatrics, school of medicine, qazvin university of medical sciences, qazvin, iran   2 department of pediatrics, school of nursing and midwifery, tehran university of medical sciences, tehran, iran     received: 22 jan 2011, accepted: 23 jun 2011       abstract     introduction: regarding the importance of me...

background: 49, xxxxy syndrome is a rare sex chromosomal disorder, occurring in 1 per 85,000-100,000 male births. the classical phenotype is ambiguous genitalia, facial dysmorphism, mental retardation and a combination of cardiac, skeletal and other malformations. case: a two month-old boy with intrauterine growth restriction (iugr) and low birth weight, facial dysmorphism, clinodactyly in feet...

backgroundeach year about 32.4 million of children are born with low birth weight, which is below the 10th percentile for their gestational ages; moreover, about fifteen million of them are premature. actually, about 60% of neonatal deaths occur in low birth weight neonates related to their prematurity. this study aimed to determine the neonatal death rate and the most common causes of the hosp...

BACKGROUND MEGDEL (3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome) syndrome is a mitochondrial disorder associated with recessive mutations in SERAC1. OBJECTIVES To report transient neonatal renal findings in MEGDEL syndrome. RESULTS This 7 year-old girl was the first child of consanguineous Turkish parents. She exhibited an acute neonatal deterioration w...

A RECENT NATIONAL STUDY indicated that illicit drug use is 16.2% among pregnant teens and 7.4% among pregnant women aged 18 to 25 years. Neonatal abstinence syndrome (NAS) is a drug withdrawal syndrome in newborns following birth. The syndrome most commonly occurs in the context of antepartum opiate use, although other drugs have also been implicated. In addition to NAS, illicit drug use (speci...