Bile reflux has been implicated in the neoplastic progression of Barrett's esophagus (BE). Bile salts increase proliferation in a Barrett's-associated adenocarcinoma cell line (SEG-1 cells) by activating ERK and p38 MAPK pathways. However, it is not clear that these findings in cancer cells are applicable to non-neoplastic cells of benign BE. We examined the effect of bile salts on three human ...

A 7-month-old castrated male French Bull dog was presented with vomiting, lethargy, anorexia and weight loss of 2 weeks duration. The patient's history and clinical manifestations of suspected hepatopathy were subjected to ultrasonography, radiography, biochemical investigations and cytology of hepatic lesion. The cytologic impression was hepatic lymphoma, which was later confirmed by histopath...

Neoplastic lymphocytes from 3 patients with aleukemic cutaneous T-cell lymphoma were studied to determine if their neoplastic T cells had helper activity. i.e., ability to promote immunoglobulin synthesis by normal human B cells. Homogeneous populations of neoplastic T cells were isolated from involved lymph nodes and in two of three instances were shown to be of monoclonal origin by karyotypic...

A case of lymphoma of T-cell derivation with aberrant expression of three B-cell lineage markers (CD19, CD20, and CD79a), which was diagnosed on a left axillary excision, is described. Immunohistochemical studies and flow cytometry analysis demonstrated neoplastic cells expressing CD3, CD19, CD20, and CD79a with absence of CD4, CD8, CD10, CD30, CD34, CD56, CD68, TDT, MPO, PAX-5, and surface imm...

A haemic neoplasm occurs in populations of the common cockle Cerastoderma edule L. along the coast of Ireland. The morphology, epizootiology and distribution of the disease have previously been described. The aetiology of the neoplasm is unknown. In this study transmission of the neoplasm between cockles was accomplished using both whole neoplastic cells and neoplastic cell-free homogenates whi...

Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked. In epithelia, pre-neoplastic transformation stages are often distinguished by the appearance of phenotypic features of another differentiated tissue, termed metaplasia. In haema...

Abstract Background Focal lesions of the kidney comprise a spectrum entities that can be broadly classified as malignant tumors, benign and non-neoplastic lesions. Malignant tumors include renal cell carcinoma subtypes, urothelial carcinoma, lymphoma, post-transplant lymphoproliferative disease, metastases to kidney, rare Benign angiomyolipoma (fat-rich fat-poor) oncocytoma. Non-neoplastic infe...

An immunoperoxidase technique for the optical microscopic detection of cellular immunoglobulin has been used to stain fixed smears of human neoplastic B lymphoid cells. Only four out of 28 cases of chronic lymphatic leukaemia (CLL) showed membrane labelling by this technique. In contrast, when 14 samples from other types of B lymphoproliferative disorder (including hairy cell leukaemia, non-Hod...