Other names: CCN1, GIG1, IGFBP10 HGNC (Hugo): CYR61 Location: 1p22.3 Note CYR61 (cysteine-rich angiogenic inducer 61; also named CCN1), first identified as a serum-inducible immediate-early gene, encodes a secreted, extracellular matrix-associated protein that regulates diverse cellular functions (Lau, 2011). CYR61 and five later identified homologs comprise the six-member CCN family, named aft...

Berry, Colin L., Keeling, Jean, and Hilton, Clare (1970). Archives of Disease in Childhood, 45, 229. Coincidence of congenital malformation and embryonic tumours of childhood. Examination of the records of cases of neuroblastoma, nephroblastoma, hepatoblastoma, and teratoma has not revealed a significant association between neoplasia and malformation. An increase in 'local' abnormalities in sac...

Received: May 26, 2004 Accepted: September 15, 2004 Neoplastic diseases have not been widely studied in pigs, although prevalence in slaughter animals has been recorded in several countries in the past four decades. Since most swine are slaughtered at 6 months of age or younger, the most common tumors diagnosed are those that commonly occur in young animals, ie, lymphosarcoma, nephroblastoma, a...

Familial Wilms tumor is a rare entity that accounts for only 1-2% of all Wilms tumor cases, with an earlier age of onset and an increased frequency of bilateral tumors. Teratoid Wilms tumor is a variant of nephroblastoma with a predominance of heterologous tissues comprising more than 50% of the tumor volume. Wilms tumor does not usually secrete any specific tumor marker and all teratoid Wilms ...

Diagnosis of tumors of the kidney depends principally on clinical evaluation and radiologic studies. The role of the pathologist is most important in the classification and characterization of the tumors. In addition, morphologic studies employing the use of electron microscopy may aid in the understanding of histogenesis and the recognition of tumor sub-types. Electron microscopic evaluation i...

Sacrococcygeal teratoma with nephroblastic elements is very rare. Only 8 cases have been reported up to date. 3 cases were misdiagnosed as extrarenal nephroblastomas and were administered excessive treatments such as chemotherapy and radiation therapy. It has a great significance to distinguish sacrococcygeal teratoma with nephroblastic elements from extrarenal nephroblastoma for their differen...

Renal neoplasia is rare in the horse and the presenting signs are varied and frequently nonspecific. Several types of renal tumour have been reported including nephroblastoma, transitional cell carcinoma and squamous cell carcinoma, although renal cell carcinomas are the most common (Schott 2004). Eighteen cases have been reported in detail in the veterinary literature since 1980. These reports...