BACKGROUND Diabetic dermopathy has been termed the most common cutaneous finding in diabetes, occurring in as many as 40% of diabetic patients older than 50 years. Using laser Doppler technology, we tested the hypothesis that dermopathy lesions represented areas of cutaneous ischemia. DESIGN A survey of cutaneous blood flow in diabetic patients with dermopathy and comparison of values with th...

Restrictive dermopathy is a rare and lethal autosomal recessive genodermatosis characterized by tight skin, typical dysmorphic face, generalized arthrogryposis and pulmonary hypoplasia. Infants with restrictive dermopathy have similar findings in skin biopsy, but other abnormalities are unremarkable. We report a male preterm infant with restrictive dermopathy. The post-mortem examination reveal...

BACKGROUND Diabetic dermopathy is one of the most prevalent skin complications in diabetes patients. Some studies have pointed to association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes as microangiopathy presentations, but no rigorous study has been conducted to confirm this association. OBJECTIVES This study investigated association of diabetic d...

Correspondence to: Dr Kei Pin Lin Tel: (65) 6222 3322 Fax: (65) 6326 5242 Email: binglin8@ yahoo.com.sg Nephrogenic systemic fibrosis (NSF) is a rare multisystem disease characterised by widespread tissue fibrosis. It is recognised for its epidemiological association in patients with chronic renal failure, after administration of gadolinium-chelate magnetic resonance (MR) contrast agent, partic...

Nephrogenic systemic fibrosis (NSF) is a recently characterized systemic fibrosing disorder developing in the setting of renal insufficiency. NSF's rapidly progressive nature resulting in disability within weeks of onset makes early diagnosis important. Two reports of NSF after liver transplantation are known of. We present three cases of NSF developing within a few months after liver transplan...

Introduction: Renal artery stenosis (RAS) is a well-known cause of renal hypertension and can lead to chronic kidney failure. The recent connection between gadolinium contrast agents and nephrogenic systemic fibrosis (NSF) has prompted renewed interest in non-contrast enhanced MR angiography (NCE MRA) for the diagnosis of RAS, most notably methods based on 3D balanced steady-state free precessi...

Background Since 2006, the US Food and Drug Administration (FDA) has recommended restricting gadolinium based contrast agents (GBCAs) for magnetic resonance in patients with renal impairment due to an association of GBCA use with nephrogenic systemic fibrosis (NSF). The multiple FDA warnings have listed different glomerular filtration rate (GFR) cut-off values for restricting GBCA use. Conseque...

PURPOSE To retrospectively determine the incidence of nephrogenic systemic fibrosis (NSF) in a large academic medical center after the adoption of restrictive gadolinium-based contrast agent (GBCA) administration guidelines. MATERIALS AND METHODS For this retrospective HIPAA-compliant study, institutional review board approval was obtained and the requirement for informed consent was waived. ...