OBJECTIVE To investigate whether fibromyalgia induces axonal damage in the optic nerve that can be detected using optical coherence tomography (OCT), as the retinal nerve fiber layer (RNFL) is atrophied in patients with fibromyalgia compared with controls. METHODS Fibromyalgia patients (n = 116) and age-matched healthy controls (n = 144) were included in this observational and prospective coh...

SIGNIFICANCE This study resulted in the identification of an optic nerve head (ONH) feature associated with tilted optic discs, which might potentially contribute to ONH pathologies. Knowledge of such findings will enhance clinical insights and drive future opportunities to understand disease processes related to tilted optic discs. PURPOSE The aim of this study was to identify novel retinal ...

The transretinal pathway of optic nerve fibers in the retinas of cynomolgus and bonnet monkeys was studied by light microscopy following small intraretinal injections of horseradish peroxidase (HRP). Injections of HRP into nerve bundles at the optic disc labeled a few ectopic ganglion cells, in addition to those in the related retinal sector. Injections into nerve bundles in the retina labeled ...

PURPOSE To measure retinal nerve fiber layer (RNFL) thickness in a population-based setting. METHODS In the population-based Beijing Eye Study 2011 with 3468 individuals, RNFL thickness was measured in a subgroup of 1654 (47.7%) study participants by spectral domain optical coherence tomography (iVue SD-OCT). RESULTS Mean RNFL thickness was significantly (P<0.001) higher in the inferior sec...

PURPOSE Compare performance of normalized reflectance index (NRI) and retinal nerve fiber layer thickness (RNFLT) parameters determined from optical coherence tomography (OCT) images for glaucoma and glaucoma suspect diagnosis. METHODS Seventy-five eyes from 71 human subjects were studied: 33 controls, 24 glaucomatous, and 18 glaucoma-suspects. RNFLT and NRI maps were measured using 2 custom-...

OBJECTIVE To assess possible differences in the retinal nerve fiber layer (RNFL) thickness between children with strabismus and controls. This study also compared esotropia with exotropia cases, and dominant eyes with non-dominant eyes. METHOD 31 children with esotropia, 17 children with exotropia and 32 controls were studied. The peripapillary RNFL average thickness was determined in 4 diffe...

An image analysis method to measure retinal nerve fiber layer (RNFL) striations from digitized fundus photographs was developed to improve detection and monitoring of progressive diffuse RNFL loss. Striations were measured by comparing the high spatial frequency variability across with the variability along the RNFL. This locally normalized measure of striations compensates for the wide density...

BACKGROUND AND PURPOSE Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS Patients with acute ischemic stroke as part of a hospital-based study group were compared with the participants of the population-based group Beijing Eye Study. The retina ...

The nerve fiber layer of the human retina is made up of the retinal segments of ganglion cell axons. Its geometry can be described mathematically as a fibration of a 2D domain: a partition of a certain region into smooth curves. Here, we present a simple family of curves that closely models the observed geometry of the nerve fiber layer. For each retina, the pattern depends on 2 parameters, A a...

PURPOSE The brain areas that are responsible for cognitive functioning have the same embryonic origin as the retina. The association between cognitive functioning and retinal nerve fiber layer (RNFL) thickness was assessed in a large, population-based sample. METHODS Neuropsychological and ophthalmic examinations were performed in 1485 healthy individuals (mean age, 46 years; range, 18-85) fr...