The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. In this review, we discuss the factors that regulate proliferation and fate determination of adult neural stem cells and describe recent studies concerning the integration of newborn neurons into the existing neural circuitry. We further...

We develop machine learning methods to decipher the neural code that links perception with the firing of neurons in the cerebral cortex. We deploy Bayesian graphical models for holistic neuron data analysis to provide a framework for understanding the neural circuitry, which is unattainable with current single neuron methods. The proposed models are data-driven and capture the probabilistic con...