Visual transduction in Drosophila is a G protein-coupled phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel. Inactivation-no-afterpotential D (INAD) is an adaptor protein containing PDZ domains known to interact with TRP. Immunoprecipitation studies indicate that INAD also binds to eye-specific protein kinase C ...

Six Sigma is a concept, a process, a measurement, a tool, a quality philosophy, a culture and a management strategy for the improvement in the system of an organization, in order to reduce wastages and increase the profit to the management and satisfaction to the customers. Six Sigma is a business improvement approach and management philosophy that seeks to find and remove causes of defects/err...

Absolute visual thresholds are limited by "dark noise," which in Drosophila photoreceptors is dominated by brief (∼10 ms), small (∼2 pA) inward current events, occurring at ∼2/s, believed to reflect spontaneous G protein activations. These dark events were increased in rate and amplitude by a point mutation in myosin III (NINAC), which disrupts its interaction with the scaffolding protein, INAD...

The TRP family of ion channels mediates a wide range of calcium-influx phenomena in eukaryotic cells. Many members of this family are activated downstream of phosphoinositide hydrolysis but the subsequent steps that lead to TRP channel activation in vivo remain unclear. Recently, the lipid products of phosphoinositide hydrolysis (such as diacylglycerol and its metabolites) have been implicated ...

When the extracellular concentration of glucose was raised from 3 mm to 7 mm (the concentration interval in which fl-cell depolarization and the major decrease in K+ permeability occur), the cytosolic free [NADPH]/ [NADP+] ratio in mouse pancreatic islets increased by 29.5% . When glucose was increased to 20 mm, a 117% increase was observed. Glucose had no effect on the cytosolic free [NADH]/[N...

Human motor activity has a robust, intrinsic fractal structure with similar patterns from minutes to hours. The fractal activity patterns appear to be physiologically important because the patterns persist under different environmental conditions but are significantly altered/reduced with aging and Alzheimer's disease (AD). Here, we report that dementia patients, known to have disrupted circadi...

Calcium signaling is an important mediator of neuropeptide-stimulated fluid transport by Drosophila Malpighian (renal) tubules. We demonstrate the first epithelial role, in vivo, for members of the TRP family of calcium channels. RT-PCR revealed expression of trp, trpl, and trpgamma in tubules. Use of antipeptide polyclonal antibodies for TRP, TRPL, and TRPgamma showed expression of all three c...

Rural development for objective 1 regions is also promoted through specific Integrated Plans, to be realized through the definition of Socio-Economic Partnerships. The members of these Partnerships are public and private subjects which represent the interests of local people and of the Government. The members of a Socio-Economic Partnership play different roles in society and thus have differen...

INTRODUCTION Atrial fibrillation (AF), the world's most common arrhythmia, often goes undetected and untreated in low-resource communities, including India, where AF epidemiology is undefined. AF is an important risk factor for stroke, which plagues an estimated 1.6 million Indians annually. As such, early detection of AF and management of high-risk patients is critically important to decrease ...

BACKGROUND Physical activity levels are low amongst adolescent girls, and this population faces specific barriers to being active. Peer influences on health behaviours are important in adolescence and peer-led interventions might hold promise to change behaviour. This paper describes the protocol for a feasibility cluster randomised controlled trial of Peer-Led physical Activity iNtervention fo...