BACKGROUND Transcobalamin II is a serum transport protein for vitamin B12. Small variations in TC-II affinity were recently linked to a high homocysteine level and increased frequency of neural tube defects. Complete absence of TC-II or total functional abnormality causes tissue vitamin B12 deficiency resulting in a severe disease with megaloblastic anemia and immunologic and intestinal abnorma...

BACKGROUND Large skeletal defects due to postosteomyelitis are uncommon, and they present a challenging reconstructive problem. The aim of our study was to summarize our experience performing a distraction osteogenesis technique using an intramedullary nail and a monolateral external fixator in the reconstruction of massive postosteomyelitis skeletal defects of the femur. METHODS Between Janu...

inborn errors of organic acid metabolism are relatively recently recognized diseases with a wide spectrum of clinical signs and symptoms: ranging from asymptomatic, normal appearing children to death during first few days of life.in my presentation i will try to explain some of the most common clinical presentation of these disorder with stress on neurologic findings. organic acidemia usually h...

idiopathic hypereosinophilic syndrome represents a heterogeneous group of leukoprolifrative disorders associated with prolonged eosinophilia of an undetectable cause with multi organ system dysfunction. it is a rare group disorder in children, most cases are reported in adult age group. we report a child with this syndrome who along with the usual features of the syndrome also had the presentat...

background: in this study we sought to investigate clinical findings (with a focus on neurologic effects) and also to analyze outcomes of a series of patients with methanol poisoning admitted to two poisoning treatment centers in tehran, iran. methods: in this prospective cross-sectional study, methanol-poisoned patients admitted to departments of forensic medicine and toxicology of loghman hak...

traumatic retrolisthesis is a rare injury and may result in intervertebral disc extrusion and nerve root injury. these injuries are highly unstable and require surgery for decompression and stabilization. traumatic retrolisthesis of l5 with acute l5/s1 disc extrusion associated with nerve root injury has not been reported previously in english literatures. we herein report a case of traumatic r...