OBJECTIVE In the present study, we aimed to determine the protective effect of the perfusion of the distal aorta with diltiazem and ringer lactate solution on the spinal cord. METHODS Twenty-seven New Zealand rabbits were used in which spinal cord ischemia was provided by occlusion of the aorta for thirty minutes. Experimental animals were divided into four groups: group A (n=4), the sham ope...

Transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for repair of traumatic brain injury has been used in the clinic. Hyperbaric oxygen (HBO) treatment has long been widely used as an adjunctive therapy for treating traumatic brain injury. UC-MSC transplantation combined with HBO treatment is expected to yield better therapeutic effects on traumatic brain injury. In this ...

The purpose of this study is to identify the relationship between trauma severity and the degree of cord injury in patients with ossification of posterior longitudinal ligament (OPLL). Four-hundred-one patients were classified into Group A (OPLL(+)), Group B (spinal stenosis (+) and OPLL(-)), and Group C (OPLL (-) and spinal stenosis(-)). Trauma severity and neurological injury severity were co...

The vast majority of combat-related penetrating spinal injuries from gunshot wounds result in severe or complete neurological deficit. Treatment is based on neurological status, the presence of cerebrospinal fluid (CSF) fistulas, and local effects of any retained fragment(s). We present a case of a 46-year-old male who sustained a spinal gunshot injury from a 7.62-mm AK-47 round that became lod...

Study Design: Retrospective cohort study using aggregated data from our institute. Objective: To examine the effects of hypotension requiring catecholamine (dopamine and epinephrine) administration on neurologic recovery in acute cervical spinal cord injury (SCI). Summary of Background Data: Following spinal cord injury, traumatic blood loss and spinal shock can occur causing low blood pressure...

Although brain injury is known to be associated with feeding outcomes in preterm and unwell neonates, these groups are frequently excluded from studies of neonatal development. This paper aims identify the short-term infants injury. A retrospective cohort analysis was undertaken ascertain incidence disorders (full/partial tube at 40 weeks) among admitted a UK unit between 2013 2017. 202 survivi...

Spinal Cord injury is a disabling condition which affects the respiratory system. The most affected neurological level cervical spine. Many patients with spinal cord are unable to sustain independent ventilation and require mechanical ventilation. Long term use of associated poor quality life, increased morbidity, mortality. In intact phrenic nerve, diaphragmatic pacing can be used help wean of...

INTRODUCTION We report the effective use of dexmedetomidine in the treatment of a patient with a history of chronic alcohol abuse and an acute traumatic brain injury who developed agitation that was unresolved if from traumatic brain injury, or alcohol withdrawal or the combination of both. Treatment with benzodiazepines failed; lorazepam therapy obscured our ability to do reliable neurological...

AIM Burst fractures can occur with different radiological images after high energy. We aimed to simplify radiological staging of burst fractures. METHODS Eighty patients whom exposed spinal trauma and had burst fracture were evaluated concerning age, sex, fracture segment, neurological deficit, secondary organ injury and radiological changes that occurred. RESULTS We performed a new classif...

Despite of the huge socio-economic burden, stroke still represents an unmet therapeutic need. Researchers failed to reproduce preclinical efficacy in subsequent clinical development. To bridge this translation failure, the Stroke Therapy Academic Industry Round Table (STAIR) has suggested a rigorous, robust, and detailed preclinical evaluation in at least 2 species and multiple cerebral ischemi...