The data is obtained from exploring the modulatory activities of bioflavonoids on P-glycoprotein function by ligand-based approaches. Multivariate Linear-QSAR models for predicting the induced/inhibitory activities of the flavonoids were created. Molecular descriptors were initially used as independent variables and a dependent variable was expressed as pFAR. The variables were then used in MLR...

A series of 21 compounds isolated from Curcuma zedoaria was subjected to cytotoxicity test against MCF7; Ca Ski; PC3 and HT-29 cancer cell lines; and a normal HUVEC cell line. To rationalize the structure-activity relationships of the isolated compounds; a set of electronic; steric and hydrophobic descriptors were calculated using density functional theory (DFT) method. Statistical analyses wer...

The mesencephalic (or midbrain) locomotor region (MLR) was first described in 1966 by Shik and colleagues, who demonstrated that electrical stimulation of this region induced locomotion in decerebrate (intercollicular transection) cats. The pedunculopontine tegmental nucleus (PPT) cholinergic neurons and midbrain extrapyramidal area (MEA) have been suggested to form the neuroanatomical basis fo...

2(1H)-pyrimidinone,5-(3-methylphenoxy) (MLR-1023) is a candidate for the treatment of type 2 diabetes. The current studies were aimed at determining the mechanism by which MLR-1023 mediates glycemic control. In these studies, we showed that MLR-1023 reduced blood glucose levels without increasing insulin secretion in vivo. We have further determined that MLR-1023 did not activate peroxisome pro...

Quantitative structure–activity relationship (QSAR) approaches were used to estimate the volume of distribution (Vd) using an artificial neural network (ANN). The data set consisted of the volume of distribution of 129 pharmacologically important compounds, i.e., benzodiazepines, barbiturates, nonsteroidal anti-inflammatory drugs (NSAIDs), tricyclic anti-depressants and some antibiotics, such a...

Drought forecasting is essential for risk management and preparedness of drought mitigation measures. The present study aims to evaluate the effectiveness proposed hybrid technique regional forecasting. Multiple Linear Regression (MLR), Artificial Neural Network (ANN), two wavelet techniques, namely, Discrete Wavelet Transform (DWT) Packet (WPT), were evaluated in up a lead time six months. Sta...

BACKGROUND The complete blood count (CBC) is the most common examination used to monitor overall health in clinical practice. Whether there is a relationship between CBC indexes and alanine transaminase (ALT) and aspartate aminotransferase (AST) has been unclear. MATERIAL AND METHODS In this study, 572 normal-weight and 346 overweight Chinese subjects were recruited. The relationship between CB...

Maximal oxygen uptake (VO2max) is one of the most distinguished parameters in endurance sports and plays an important role, for instance, in predicting endurance performance. Different models have been used to estimate VO2max or performance based on VO2max. These models can use linear or nonlinear approaches for modeling endurance performance. The aim of this study was to estimate VO2max in hea...

Cloud computing is a recent and significant development in the domain of network applications with a new information technology perspective. This study attempts to develop a hybrid model to predict motivators influencing the adoption of cloud computing services by information technology (IT) professionals. The research proposes a new model by extending the Technology Acceptance Model (TAM) with...

Maximal oxygen uptake (VO2max) is one of the most distinguished parameters in endurance sports and plays an important role, for instance, in predicting endurance performance. Different models have been used to estimate VO2max or performance based on VO2max. These models can use linear or nonlinear approaches for modeling endurance performance. The aim of this study was to estimate VO2max in hea...