The human insulin receptor gene, INSR, and its promoter region have been isolated and characterized. The gene spans greater than 120 kilobase pairs (kbp) and has 22 exons. All introns interrupt protein coding regions of the gene. The 11 exons encoding the alpha subunit of the receptor are dispersed over greater than 90 kbp, whereas the 11 exons encoding the beta subunit are located together in ...

Functional characterization of oncogene products that induce cellular transformation has progressed rapidly in recent years. However, less is known about the mechanism(s) by which the transformed cells may escape destruction by host immune defenses and form tumors. A recently described oncogene that has an important association with aggressive human breast carcinoma is "HER2," for human epiderm...

G-protein coupled receptors (GPCRs) are key players in signal transduction and therefore a large proportion of pharmaceutical drugs target these receptors. Structural data of GPCRs are sparse yet important for elucidating the molecular basis of GPCR-related diseases and for performing structure-based drug design. To ameliorate this problem, GPCR-SSFE 2.0 (http://www.ssfa-7tmr.de/ssfe2/), an int...

The seasonal variations in the occurrence and distribution of pharmaceuticals were evaluated in seawater and sediment of Mar Menor lagoon from spring 2010 to winter 2011. A total of 20 pharmaceuticals in seawater and 14 in sediments were found at concentrations from low ngL(-)(1) up to 168ngL(-)(1) (azithromycin) in seawater and from low ngg(-1) up to 50.3ngg(-1) (xylazine) in sediments. Azithr...

Natural gas is often associated with nitrogen and heavy compounds. The Heavy components in the natural gas not only can feed downstream units, owing to the low temperature process may be formed solid as well. Therefore, heavy components separation can be a necessity and produce useful products. Virtually, all natural gases are containing nitrogen ​​that would lower the heating value of natural ...

Abstract. We developed a high-quality global integrated water vapour (IWV) dataset from 12 552 ground-based positioning system (GPS) stations in 2020. It consists of 5 min GPS IWV estimates with total number 1 093 591 492 data points. The completeness rates the are higher than 95 % at 7253 (58 %) stations. is an enhanced version existing operational provided by Nevada Geodetic Laboratory (NGL)....

In this work, we developed a method based on ultrasound-assisted emulsification microextraction (USAEME) for the determination of zinc and copper by flame atomic absorption spectrometry (FAAS). The method is based on the use of the organic solvent carbon tetrachloride (CCl4) as an extraction solvent. In order to obtain a high enrichment factor, the effect of different parameters affecting the c...

Precipitable water vapor (PWV) is an important component in the climate system and plays a pivotal role global energy cycles. Over years, many approaches have been devised to accurately estimate PWV. Among them, navigation satellite systems (GNSS) become one of most promising fastest-growing PWV acquisition methods because its high accuracy, temporal spatial resolution, ability acquire all weat...