Chronic granulomatous disease (CGD) is an extremely rare genetically heterogeneous disorder characterized by serious life-threatening infections. CGD caused a defect of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system. The increased inflammation and granuloma formation secondary to recurrent typically involves lungs, liver, lymph nodes. Most patients with are diagnosed in ...

Nicotinic acid adenine dinucleotide phosphate (NAADP)2 is a metabolite of NADP that was first identified as the most potent Ca2 stores mobilizing molecule in sea urchin egg homogenates more than a decade ago (1, 2). It has since been shown to be effective in a wide variety of cells, from plant to animal, including human (reviewed in Refs. 3–5). Its mechanism of action is distinct from those of ...

Neurospora NADP-specific glutamate dehydrogenase that was treated with iodoacetate, iodoacetamide, or N-ethylmaleimide to block the thiol groups was cleaved with cyanogen bromide. Of the expected 10 peptides, based on a methionine content of 9 residues, 8 were obtained in pure form and 2 were handled as a mixture. The fragments ranged in size from 9 to 109 residues. In addition, there were isol...

Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+ release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+ signaling. The...

The site of action of the inhibitors disalicylidenepropanediamine and pyrophosphate was more closely defined as acting on ferredoxin. Three inhibitors which act on the electron transport path between ferredoxin and NADP: disalicylidenepropanediamine, pyrophosphate, and phosphoadenosinediphosphate ribose, had no effect on photosynthesis in cell free preparations of Dunaliela parva at concentrati...

Apocynin (4-hydroxy-3-methoxyacetophenone), isolated from the traditional medicinal plant Picrorhiza kurroa, is a naturally occurring methoxy-substituted catechol, experimentally used as an inhibitor of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase.1 Activated neutrophil NADPH oxidase, a multisubunit complex composed of membrane-associated gp91phox (Nox2) and p22phox and c...

There is a lack of consensus about the effects of the type of menopause (surgical or natural) and of oestrogen replacement therapy on Parkinson's disease. The effects of the timing of replacement therapy and the female's age may explain the observed differences in such effects. However, the mechanisms involved are poorly understood. The renin-angiotensin system mediates the beneficial effects o...

We report an unusual phenotype of congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome most likely resulting from a novel X-chromosomal microdeletion encompassing the promoter region and exon 1 of the nicotinamide adenine dinucleotide phosphate steroid dehydrogenase-like protein gene, the neighboring gene CETN2, and more than 10 kb of noncoding deoxyribonucleic acid.

Reduced nicotinamide-adenine dinucleotide phosphate (NADPH), required as co-factor for lipogenesis and steroidogenesis, may, in part, be supplied by pyridine nucleotide transhydrogenation mediated by malate dehydrogenase (oxaloacetate+NADH\ar=r\malate+NAD) and the malate (`malic') enzyme (malate+NADP\ar=r\pyruvate+CO2 +NADPH). The malate transhydrogenation reactions (cf. Ballard & Hanson, 1967,...

An enzyme is present in extracts of guinea pig polymorphonuclear leukocytes which can catalyze the hydrolysis of pyridine nucleotides. The enzyme is equally active toward nicotinamide adenine dinucleotide (NAD) or NAD phosphate, has an acid pH optimum, and is inhibited by either nicotinamide or isonicotinic acid hydrazide. This enzyme might be involved in the regulation of the pyridine nucleoti...