نتایج جستجو برای: nipam

تعداد نتایج: 208  

Journal: :Soft matter 2016
Samantha Micciulla Olaf Soltwedel Oliver Löhmann Regine von Klitzing

The complex interaction of polyelectrolyte multilayers (PEMs) physisorbed onto end-grafted polymer brushes with focus on the temperature-responsive behavior of the system is addressed in this work. The investigated brush/multilayer composite consists of a poly(styrene sulfonate)/poly(diallyldimethylammonium chloride) (PSS/PDADMAC) multilayer deposited onto the poly(N-isopropylacrylamide-b-dimet...

2015
G. Roshan Deen Vivien Chua Dirk Kuckling

Hydrogel nanocomposites containing silver nanoparticles of size 15–21 nm were prepared by diffusion and in-situ chemical reduction in chemically crosslinked polymers based on N-acryloyl-N′-ethyl piperazine (AcrNEP) and N-isopropylacrylamide (NIPAM). The polymer chains of the hydrogel network offered control and stabilization of silver nanoparticles without the need for additional stabilizers. T...

2015
Kyunghee Cho Jennifer B. Fasoli Keiichi Yoshimatsu Kenneth J. Shea Robert M. Corn

This paper describes how changes in the refractive index of single hydrogel nanoparticles (HNPs) detected with near-infrared surface plasmon resonance microscopy (SPRM) can be used to monitor the uptake of therapeutic compounds for potential drug delivery applications. As a first example, SPRM is used to measure the specific uptake of the bioactive peptide melittin into N-isopropylacrylamide (N...

2008
Jun-Hyun Kim

This paper describes the preparation and characterization of a new type of composite nanoparticle, where the structure consists of a nontoxic hydrogel polymer network that encapsulates a gold shell/silica core. These composite nanoparticles are being developed as photothermally responsive drug-delivery vehicles that undergo structural changes slightly above physiological temperature. A unique p...

Journal: :iranian journal of basic medical sciences 0
elham khodaverdi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran omid rajabi department of medicinal chemistry, school of pharmacy, mashhad university of medical sciences, mashhad, iran mohammad abdekhodai department of pharmaceutics, school of chemical engineering, sharif university, tehran, iran xiao yu wu department of pharmaceutics, school of pharmacy, university of toronto, toronto, canada

objective(s) in this study, a kind of ph sensitive composite membrane was prepared and drug permeation through it was investigated in terms of ph. rationale of this study originated from the fact that a ph change which may be a result of a disease state in the body can trigger drug release. materials and methods  here, a kind of ph sensitive composite membrane containing different nanoparticle ...

2017
Lies A. L. Fliervoet Marzieh Najafi Mathew Hembury Tina Vermonden

ABC triblock copolymers with a poly(ethylene glycol) (PEG) midblock have attractive properties for biomedical applications because of PEG's favorable properties regarding biocompatibility and hydrophilicity. However, easy strategies to synthesize polymers containing a PEG midblock are limited. In this study, the successful synthesis of a heterofunctional PEG macroinitiator containing both an az...

2000
S. Varghese A. K. Lele R. A. Mashelkar

We have shown that the lattice fluid hydrogen bond ~LFHB! model can successfully quantify the first-order volume transition in hydrogels. The model predicts that a critical balance of hydrophilic and hydrophobic interactions is required for a gel to exhibit a discontinuous volume transition. In this work we will report the swelling behavior of a new thermoreversible copolymer hydrogel, which ha...

Journal: :Biomedical materials 2012
Dan Liu Tao Wang Xinxing Liu Zhen Tong

One-end-connected short poly(ethylene glycol) (PEG) side chains were facilely introduced into the poly(N-isopropylacrylamide) (PNIPAm) nanocomposite hydrogel (NC gel) via in situ copolymerization of NIPAm monomer and PEG macromonomer in the aqueous suspension of hectorite clay Laponite XLS. The NC gels were characterized with Fourier transform infrared and x-ray photoelectron spectroscopy for t...

Journal: :International Journal of Nanomedicine 2007
Jim Moselhy Swapna Sarkar Maria C Chia Joseph D Mocanu Nicolas Taulier Fei-Fei Liu Xiao Yu Wu

Copolymers of 2-dimethyl(aminoethyl) methacrylate (PDMAEM) with N-isopropylacrylamide (NIPAM) were evaluated for their potential to enhance transgene expression of plasmid DNA (pDNA) and gene delivery by adenovirus vectors. The polymers of varying compositions and molecular weights (MW) were synthesized by free-radical polymerization. Polyelectrolyte complexes (PECs) were prepared with differen...

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