نتایج جستجو برای: nitroreductase
تعداد نتایج: 396 فیلتر نتایج به سال:
3-Nitro-1H-1,2,4-triazole-based acetamides bearing a biphenyl- or a phenoxyphenyl moiety have shown remarkable antichagasic activity both in vitro and in an acute murine model, as well as substantial in vitro antileishmanial activity but lacked activity against human African trypanosomiasis. We have shown now that by inserting a methylene group in the linkage to obtain the corresponding propana...
The ability to visualize reporter gene expression in vivo has revolutionized all facets of biologic investigation and none more so than imaging applications in oncology. Near-infrared reporter gene imaging may facilitate more accurate evaluation of chemotherapeutic response in preclinical models of orthotopic and metastatic cancers. We report the development of a cell permeable, quenched squari...
Escherichia coli nitroreductase plus CB1954 enhances the effect of radiotherapy in vitro and in vivo
(Petters et al., 1983) permits the determination of small amounts of 7-aminoclonazepam (about 20 pmol) and is thus useful for measuring low activities in various tissues. All investigated foetal livers catalysed the nitroreduction reaction at different rates. The mean activity was in the same range as that in Rhesus monkey liver, but only about 15% of the activity in human adult liver. Such dis...
Tuberculosis continues to be a global health threat, making bicyclic nitroimidazoles an important new class of therapeutics. A deazaflavin-dependent nitroreductase (Ddn) from Mycobacterium tuberculosis catalyzes the reduction of nitroimidazoles such as PA-824, resulting in intracellular release of lethal reactive nitrogen species. The N-terminal 30 residues of Ddn are functionally important but...
Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance.
Metronidazole resistance in Helicobacter pylori reportedly occurs by mutational inactivation of the oxygen-insensitive nitroreductase gene rdxA. Nucleotide sequences of rdxA were determined in a set of 46 isolates from 19 dyspeptic patients from the UK. The study set comprised matched isolates that were either metronidazole susceptible (four) or mixed metronidazole susceptible and metronidazole...
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