The formation of /V-nitroso compounds in mouse stom ach from equimolar doses of sodium nitrite and secondary amines or alkylurea derivatives given simultaneously by a stomach tube was estimated by measuring the mutagenic activity of the compounds in the i.p. host-mediated assay with the use of Salmonella typhimurium TA1950 as genetic indicator system. A mutagenic response in the bacteria was fo...

N-Nitrosocimetidine, a nitroso derivative of the drug cimetidine, was given to groups of 20 male and 20 female rats in drinking water at a concentration of 0.5 mM for more than 2 years. The life span of the rats was not decreased compared with untreated control animals, and there was no significant increase in incidence of any tumor that could be attributed to the treatment. In comparison, 45% ...

An umpolung approach toward nitrone construction utilizing a phosphine-mediated addition of 1,2-dicarbonyls to nitroso compounds is reported. The reaction exhibits a high degree of chemoselectivity and provides direct access to isoxazolidines, imines, and trisubstituted alkenes.

A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.

This paper reviews the scientific literature published from 1986 to 1999 assessing the relationship between dietary factors and brain tumors in adults. The work aimed to describe the estimated associations and to discuss methodological aspects that might influence the results. The studies generally appear to show a moderate association between dietary factors and brain tumors. There is evidence...

The formation of discrete complexes [M(mcoe)2S2] (M = Cu, Ni; S = MeOH, H2O) vs. a nitroso-bridged ferromagnetically-coupled Cu(II) coordination polymer [Cu(mcoe)2] is influenced by the use of solvothermal reaction conditions.

The first examples of hetero Diels-Alder reaction of masked o-benzoquinones with nitroso dienophiles leading to novel and highly functionalized heterocycles, which are potential intermediates for nitrogenous natural products are reported.

The crystal structure of the title compound, C8H10N2O3S, displays predominant C-H⋯O hydrogen-bonding and π-π stacking inter-actions. The hydrogen bonds are between the O atoms of the sulfonyl group and H atoms on methyl groups. The π-π stacking inter-actions occur between adjacent aromatic rings, with a centroid-centroid distance of 3.868 (11) Å. These inter-actions lead to the formation of cha...

The crystal structure of the nitrosomethane adduct of human Hb shows N-binding of the MeNO ligands to heme Fe. The structure of the EtNO adduct reveals a surprising 4.9 Å heme slippage in the β subunit, and explains the ability of C-nitroso compounds to degrade Hb removing it from circulation.