Abstract Chorioamnionitis is infection or inflammation of the chorion, amnion, and placenta. associated with 40–70% preterm births increases risk many immune-mediated neonatal sequelae. also developing wheezing asthma later in life. With this mind, we sought to characterize innate immune dysfunction chorioamnionitis. We hypothesized that infant mice exposed chorioamnionitis would display dampen...

Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays major functions in cellular physiology and metabolism as the prosthetic group of diverse proteins. Once released from cells and from hemeproteins free heme causes oxidative damage and inflammation, thus acting as a prototypic damage-associated molecular pattern. In this context, free heme is a critical comp...

Multiple sclerosis (MS) is one of the most common neuroinflammatory disorders that causes disability in the young adults. In this disease immune-driven demyelination and following that inefficient remyelination occurs. Therapies for this disease are limited, especially those to enhance myelin repair. Cellular reprogramming using defined genetic factors is a way to produce remyelinating Oligoden...

The biological importance of the ubiquitin-proteasome system in the control of myriad cellular processes has been well-recognized; however, the pathophysiological significance of the immunoproteasome, the inducible form of the proteasome, has not been well-comprehended until lately. The primary function of the immunoproteasome was originally believed to improve MHC-I antigen presentation. It no...

Space flight and models that created conditions similar to those that occur during space flight have been shown to affect a variety of immunological responses. These have primarily been cell-mediated immune responses including leukocyte proliferation, cytokine production, and leukocyte subset distribution. The mechanisms and biomedical consequences of these changes remain to be established. Amo...

background: cutaneous leishmaniasis (cl) is a parasitic disease in most parts of iran, especially in the isfahan province. the most common form of cl is a self-healing lesion but in rare situations, infection might develop to non-healing forms. clinical symptoms and treatment process might be influenced by several agents such as host immune response and parasite strains. in this study, the isol...

Measles remains a significant childhood disease, and is associated with a transient immune suppression. Paradoxically, measles virus (MV) infection also induces robust MV-specific immune responses. Current hypotheses for the mechanism underlying measles immune suppression focus on functional impairment of lymphocytes or antigen-presenting cells, caused by infection with or exposure to MV. We ha...

Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC  chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pai...