Carcinoma of male breast is uncommon as it accounts for 0.7% of total breast cancer. The pathology of male breast cancer is remarkably similar to that of cancers seen in women. The same histological subtypes of invasive cancer are present, although papillary carcinomas (both invasive and in situ) are more common and lobular carcinomas are less common. The predominant histological type, in males...

BACKGROUND Women living with HIV (WLWH) are at increased risk of invasive cervical cancer (ICC). International HIV guidelines suggest cervical screening twice the first year after HIV diagnosis and thereafter annually. Adherence to the HIV cervical screening program in Denmark is unknown. METHODS We studied women from a population-based, nationwide HIV cohort in Denmark and a cohort of age-ma...

chronic bronchopulmonary disorders occurred in a large number of rustic females who used to bake bread at their dwellings under unhgyienic conditions. bronchoscopy revealed advanced pathological changes with characterised black areas infiltrating the bronchial walls. findings in ten patients who referred with acute chronic respiratory symptoms and a positive history of indoor pollution are desc...

purpose: to characterize keratic precipitate (kp) morphology in different forms of uveitis. methods: one hundred and twenty nine eyes of 93 patients with different forms of uveitis underwent confocal scan and the morphology of kps were determined. differences in kp morphologies among different uveitic groups were evaluated.  results: age ranged from 14 to 67 years (mean: 32.5±11.2) and 58 cases...

In this study, long term dextran sulphate sodium administration was studied to ascertain whether colorectal carcinoma could be produced in patients with long standing ulcerative colitis. Simultaneously, changes in the intestinal microflora were analysed. Low grade to high grade dysplasia was seen in three of the five hamsters treated with 1% dextran sulphate sodium solution for 100 days, while ...

Induction of apoptosis by DNA-damaging agents involves the activation of mitochondrial apoptotic pathway. Aven has been identified as an antiapoptotic protein and has been shown to activate ATM in response to DNA damage. In this study, we demonstrated that enforced expression of Aven blocks UV-irradiation-, SN-38- or cisplatin-induced apoptosis upstream of mitochondria by stabilising Bcl-xL pro...

The central nervous system (CNS) tissues, including the brain, the eye, and the spinal cord, are immune-privileged, secluded from the circulation by a complex of barriers, and equipped with their own myeloid cell population, the resident microglia. Based on the classical perspective of immune-brain interactions and on the contribution of such interactions to the progression of multiple sclerosi...

Guglielmo Ronco, MD, of the Center for Cancer Epidemiology and Prevention in Turin, Italy, and colleagues pooled more than 175,000 women, aged 20 to 64, and followed them for a median of 6.5 years. The four trials used were from England (ARTISTIC), Italy (NTCC), the Netherlands (POBASCAM), and Sweden (SWEDESCREEN). A total of 107 patients had invasive cervical cancer using cancer registries and...

Despite improvements in surgical techniques and combined chemotherapies, the 5-year survival rate for all stages of non-small cell lung cancer (NSCLC) is only 18%. Understanding the function of tumor infiltrating lymphocytes (TILs) in NSCLC patient tumors will contribute to the development of rationally designed treatments and improved statistics. B cells in tumors (TIL-Bs) are detected in non-...

The ability to non-invasively monitor tumor-infiltrating T cells in vivo could provide a powerful tool to visualize and quantify tumor immune infiltrates. For non-invasive evaluations in vivo, an anti-CD3 mAb was modified with desferrioxamine (DFO) and radiolabeled with zirconium-89 (Zr-89 or 89Zr). Radiolabeled 89Zr-DFO-anti-CD3 was tested for T cell detection using positron emission tomograph...