نتایج جستجو برای: nonalcoholic steatohepatitis
تعداد نتایج: 13470 فیلتر نتایج به سال:
Ataxia-telangiectasia (A-T) is a rare disease characterized by neurodegenerative alterations, telangiectasia, primary immunodeficiency, extreme sensitivity to radiation, and susceptibility to neoplasms. A-T patients have inactivation of ataxia-telangiectasia-mutated (ATM) protein, which controls DNA double-strand break repair and is involved in oxidative stress response, among other functions; ...
BACKGROUND/AIM Nonalcoholic fatty liver disease (NAFLD) is known as the most common cause of chronic liver disease. It is accepted that the leading cause of death in patients with NAFLD is from coronary events. Blood urea nitrogen (BUN) was used as a prognostic indicator for cardiovascular disease. We aimed to investigate the relationship between BUN levels and metabolic, biochemical, and histo...
Psoriasis is an inflammatory immune-mediated disease that mainly affects the skin and is often associated with obesity, type 2 diabetes, dyslipidemia, and insulin resistance, all of which are components of the so-called metabolic syndrome.1,2 Nonalcoholic fatty liver disease is an anatomical-clinical spectrum that encompasses the mildest form of simple steatosis, nonalcoholic steatohepatitis, a...
AIMS Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary intake of fish and ω-3 fatty acids in children with biopsy-proven NAFLD, and examine their association with serological and histological indicators of dis...
Inhibition of apoptosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflammation and fibrosis in animal models of nonalcoholic steatohepatitis. We evaluated the safety and efficacy of selonsertib, a selective inhibitor of apoptosis signal-regulating kinase 1, alone or in combination with simtuzumab, in patients with nonalcoholic steatohepatitis and stage 2 or ...
Aim Nonalcoholic fatty liver disease (NAFLD) is probably the most common liver disorder in the world. A subgroup of NAFLD patients is characterized by injury to the hepatocytes and inflammation in addition to excessive fat (steatohepatitis), the latter condition is nominated nonalcoholic steatohepatitis (NASH). This work aimed to evaluate the role of probiotics on the outcome of NASH in patient...
results the relative expression of mtdna copy number was 3.7 fold higher in nafld patients than healthy controls (p < 0.0001). the results remained significant after adjustment for age, bmi, and gender (p = 0.02). in addition, the mtdna copy number was 4.3 (p < 0.0001) and 3.2-fold (p < 0.0001) higher in nonalcoholic fatty liver (nafl) and non-alcoholic steatohepatitis (nash) patients than heal...
inhibitors) are used for the treatment of hyperlipidemia accompanied by obesity, and have been shown to reduce the risk of major cardiovascular events in a prospective metaanalysis [3]. Pitavastatin is a statin that has been reported to ameliorate severe steatohepatitis by enhancing hepatic free acid β-oxidation activity in aromatase-deficient (Ar-/-) mice [4]. It has also been shown to inhibit...
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