Cancer is considered one of the most lethal diseases responsible for causing deaths worldwide. Although there have been many breakthroughs in anticancer development, cancer remains major cause death globally. In this regard, targeting cancer-causing enzymes efficient therapeutic strategies. Biological functions like cell cycle, transcription, metabolism, apoptosis, and other depend primarily on...

Abstract Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the Nucleosome Remodelling and Deacetylation (NuRD) complex that regulates gene expression. CHD4 essential for growth multiple patient derived melanoma xenografts breast cancer. Here we show expression PADI1 (Protein Arginine Deiminase 1) PADI3 in cancer cell types modulating citrullination arginine residues all...

An overdose of tramadol is a frequent reason for hepatic and renal toxicity possible death.Hence, this study aimed at investigating the impact on serum liver enzyme, oxidative stressm som antioxidant markers in male rabitts. Methods: A total 20 growing rabbits (7.5 weeks old) reared under high ambient temperature were divided into two equal groups, 10 each. The first group control administered ...

introduction: recurrent abortion (ra) may be a consequence of aberrant expression of immunological factors during pregnancy. although the relative importance of immunological factors in human reproduction remains controversial, substantial evidence suggests that autoantibodies contribute to reproductive failure. production of such antibodies is under the control of cytokines; and leptin, beside...

The effectiveness of carbohydrase enzymes has been inconsistent in corn-based swine diets; however, the increased substrate of nonstarch polysaccharides in drought-affected corn may provide an economic model for enzyme inclusion, but this has not been evaluated. A total of 360 barrows (PIC 1050 × 337, initially 5.85 kg BW) were used to determine the effects of drought-affected corn inclusion wi...

Lymphocytes were purified from peripheral blood of normal donors and patients with chronic lymphocytic leukemia (CLL) by Ficoll-Hypaque centrifugation. Adenylate cyclase activity, expressed as picomoles [(32)P]cyclic AMP generated per milligram protein per minute, was 57+/-4 in normals and 26+/-4 in CLL patients. Enzyme activity, expressed as picomoles [(32)P]cyclic AMP generated per 10(6) lymp...

OBJECTIVE To study the cause(s) of chronic dyspepsia among patients with no findings on general practice screening tests. MATERIALS AND METHODS A total of 272 consecutive patients at a general practice in Japan (125 males and 147 females, aged 14-89 years) who underwent abdominal ultrasound (US) and who had serum pancreatic enzyme (lipase or p-amylase) levels measured, were included in a 1-ye...

Follitropin was determined in the sera of 645 probands, and lutropin in the sera of 649 probands between the ages of 5 days and 18 years (neonates, infants, children and adolescents), using microparticle-enzyme-immunoassays (MEIA) on the IMx from Abbott Laboratories. The proband collective was divided into 9 age groups and each group into males and females. In accordance with the recommendation...

1. Lipoprotein lipase was separated from normal human post-heparin plasma by affinity chromatography and assayed with a 14C-labelled triolein emulsion. No enzyme activity was detected unless whole serum was included in the assay as a source of cofactor, apolipoprotein C-II. 2. After a 10 h fast, serum obtained from 46 normal subjects, eight patients with hypertriglyceridaemia but normal renal f...

It has been postulated that cancer chemo therapy utilizing metabolic antagonists may be based on quantitative differences between normal and tumor tissue. In general, neoplasms have con siderably lower enzyme and vitamin concentra tions than most normal tissues, and, in some cases, the observed levels are lower in the cancer cell than in any normal tissue. Furthermore, it is known that inhibiti...