BACKGROUND To understand cartilage oligomeric matrix protein (COMP) mechanism network from human normal adjacent tissues to lung adenocarcinoma. METHODS COMP complete different activated (all no positive correlation, Pearson CC < 0.25) and uncomplete (partly no positive correlation except COMP, Pearson CC < 0.25) network were identified in higher lung adenocarcinoma compared with lower human ...

Abstract Purpose Radiation therapy for mesothelioma remains challenging, as normal tissue toxicity limits the amount of radiation that can be safely delivered to pleural surfaces, especially dose contralateral lung. The physical properties proton result in better sparing tissues when treating pleura, both postpneumonectomy setting and lung-intact setting. Compared with photon radiation, there a...

Aberrant cytosine methylation affects regulation of hundreds of genes during cancer development. In this study, a novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter. TOX2 was unmethylated in normal cells but 28% lung (n = 190) and 23% breast (n = 80) tumors were methylated. Expression of two novel TOX2 transcripts identified was significantly reduced i...

background chronic obstructive pulmonary disease (copd) is a devastating disease.while there is no cure for copd and the lung damage associated with this disease cannot be reversed, it is still very important to diagnose it as early as possible. objectives in this paper, we propose a novel method based on the measurement of air trapping in the lungs from ct images to detect copd and to evaluate...

Abstract Objective To explored the prognostic value of pretreatment serum fibrinogen level in young patients with small cell lung cancer (SCLC). Methods The concentrations 183 (&lt;50 years old) SCLC were measured. association baseline and clinical outcome was analyzed by survival analysis. Results Hyperfibrinogenemia significantly associated American Veterans Administration Lung Study Group st...

Cytochrome P450 (CYP) enzymes expressed in human lung can metabolize a variety of xenobiotics, drugs, and endogenous compounds. Metabolism of these substrates may lead to their detoxification or activation and may affect the homeostasis of the lung, its susceptibility to disease, response to therapy, and clinical prognosis. We analyzed the expression of CYP2B7, CYP4B1, and NADPH-cytochrome P450...

This paper describes two approaches to modelling lung disease: one based on a multicompartment statistical model with a log normal distribution of ventilation perfusion ratio ( _ V= _ Q) values; and the other on a bifurcating tree which emulates the anatomical structure of the lung. In the statistical model, the distribution becomes bimodal, when the _ V= _ Q values of a randomly selected numbe...