BACKGROUND AND PURPOSE The effects of hypothermia on global cerebral blood flow (CBF) and glucose utilization (CGU) have been extensively studied, but less information exists on a local cerebral level. We investigated the effects of normothermic and hypothermic anesthesia on local CBF (LCBF) and local CGU (LCGU). METHODS Thirty-six rats were anesthetized with isoflurane (1 MAC) and artificial...

and cardiac infarction leads to neuron dysfunction and cell death, and its after-effects such as dementia, perception injury and hemiplegia are serious problems. Excess glutamate released from the neuron, energy disorder from impaired circulation and free radical generation have been clarified as the causes leading to neuron death involved with cerebral ischemia. Busto et al. reported in 1989 t...

BACKGROUND AND PURPOSE Mild hypothermia has been shown to ameliorate neuronal damage due to cerebral ischemia. In our study, the influence of mild-to-moderate hypothermia was examined in a rabbit model of focal cerebral ischemia. METHODS After 4 hours of permanent ischemia induced by occlusion of the anterior and middle cerebral and internal carotid arteries, somatosensory evoked potentials a...

BACKGROUND AND PURPOSE The efficacy of hypothermic intervention for permanent focal ischemia has yet to be clarified. This study investigated the effect of a prolonged moderate or mild hypothermia on permanent focal ischemia in rats. METHODS Two permanent focal ischemia models in male Sprague-Dawley rats were used. Moderate (30 degrees C, in experiment 1) or mild (33 degrees C, in experiment ...

BACKGROUND All forms of surgical therapy are stressful and injurious. The problems of paralysis, renal dysfunction, and colonic ischemia associated with aortic occlusion are due to acute ischemia-reperfusion injury at the cellular level. Acute-anterior spinal cord ischemia is the most devastating outcome of these iatrogenic-ischemic events. The majority of surgical procedures are performed elec...

We investigated the role of nitric oxide (NO) in myocardial ischemia-reperfusion injury of diabetic mice with myocyte-specific overexpression of endothelial NO synthase (NOS). Four weeks after diabetes induction with streptozotocin (blood glucose approximately 29 mM), isolated isovolumic heart function and cellular NO metabolites in response to brief normothermic ischemia-reperfusion were deter...

C diseases are considered as the number one cause of death in the world. It comprises its own set of pathologies, mostly are atherosclerosis, arteriosclerosis, hypertension, congestive heart failure, cardiomyopathy, coronary heart disease, hypertrophy, myocardial infarction, and stroke. It is worthwhile to mention that ischemic heart disease continues to be the major cause of cardiac death. Fre...

There is discrepancy regarding the duration of reperfusion required using 2,3,5-triphenyl-2H-tetrazolium chloride (TTC) staining to assess myocardial infarction in an isolated, perfused heart model. Several investigators prefer long-term reperfusion (120 minutes) to determine myocardial injury, while others have used a shorter duration (30-40 minutes). We investigated whether oxygen surrounding...

Background and Purpose—The effects of hypothermia on global cerebral blood flow (CBF) and glucose utilization (CGU) have been extensively studied, but less information exists on a local cerebral level. We investigated the effects of normothermic and hypothermic anesthesia on local CBF (LCBF) and local CGU (LCGU). Methods—Thirty-six rats were anesthetized with isoflurane (1 MAC) and artificially...