Insulin is not only required by patients diagnosed with type 1 diabetes mellitus, the majority of patients with type 2 diabetes mellitus also eventually require insulin1. Insulin is the most effective and safe therapy for diabetics, if taken properly. Initiation of insulin therapy poses considerable challenges for both patients and health care providers. Common patient concerns include anxiety ...

OBJECTIVE To assess the safety and efficacy of insulin aspart (IAsp) versus regular human insulin (HI) in basal-bolus therapy with NPH insulin in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS Subjects (n = 322) who were pregnant or planning pregnancy were randomized to IAsp or HI as meal-time insulin in an open-label, parallel-group, multicenter study. Subjects had A1C < or...

Basal insulin is an important component of treatment for both type 1 and type 2 diabetes. One of the principal aims of treatment in patients with diabetes is the prevention of diabetic complications, including cardiovascular disease. There is some evidence, although controversial, that attainment of good glycemic control reduces long-term cardiovascular risk in both type 1 and type 2 diabetes. ...

Angelina L. Trujillo, MD, FACE Diabetes during pregnancy is a major risk factor for poor fetal, neonatal, and maternal outcomes; however, the risk can be greatly reduced by early institution of medical nutritional therapy and insulin treatment. Maintaining maternal glycemia as near to normal as possible reduces the risk of congenital anomalies, macrosomia, neonatal hypoglycemia, and large-for-g...

OBJECTIVE To compare the effects of bedtime NPH Insulin vs Metformin combined with Glibenclamide in patients who are obese and had secondary failure to sulphonylurea treatment. DESIGN AND METHODS Prospective, randomized, comparative study of patients having type-II diabetes, without complications with associated obesity and secondary failure to sulphonylureas. Thirty-six obese patients who co...

A ntibodies against exogenously injected insulin are common with insulin treatment but seldom have serious effects on blood glucose (1). In insulin autoimmune syndrome (IAS), however, the insulin antibody causes hy-poglycemia (2) in the absence of exoge-nous insulin treatment. Here, we report a case of type 1 diabetes with insulin antibody, whereby the patient developed nocturnal hypogly-cemia ...

Submit Manuscript | http://medcraveonline.com degludec/Tresiba®) have been proven more safer and efficacious in management of type-1 and type-2 diabetes, as compared to older or traditional insulins (Human Regular and NPH), with better glycemic control (HbA1c reductions) and less or negligible hypoglycemia; these insulin analogs are available as insulin pens and more easy to use. Furthermore, t...