Nghiên cứu được thực hiện nhằm tìm hiểu trạng sử dụng thuốc chống viêm ở bệnh nhân khớp dạng thấp đang điều trị sinh học tại Trung tâm Cơ Xương Khớp, Bệnh viện Bạch Mai. mô tả cắt ngang gồm 153 chẩn đoán và Mai trong khoảng thời gian từ tháng 8/2019 đến 8/2022. Kết quả nghiên cho thấy có 81% dùng viêm, đó nhóm glucocorticoid (GC) tỉ lệ chiếm 79%, còn không steroid (Non-steroidal anti-inflamator...

Pain remains one of the main reasons for medical consultation worldwide: moderate- to severe-intensity pain occurs in 19% of adult Europeans, seriously affecting the quality of their social and working lives. Nonsteroidal anti-inflammatory drugs (NSAIDs) are not recommended for long-term use and a careful surveillance to monitor for toxicity and efficacy is critical. This study aims to assess: ...

To the Editor: It is quite encouraging to read the TSOC Guideline article “2012 Guidelines of the Taiwan Society of Cardiology for the Management of ST-Segment Elevation Myocardial Infarction” by Li et al. 1 Though I wholeheartedly agree with and appreciate this guideline, I find it necessary to take issue with a comment about nonsteroidal anti-inflammatory drugs (NSAIDs) because the reader may...

BACKGROUND The frequency with which non-steroidal anti-inflammatory drugs (NSAIDs) increase small intestinal permeability and cause inflammation is uncertain. AIMS To examine small intestinal permeability and inflammation in a large number of patients on long term NSAIDs. METHODS Sixty eight patients receiving six different NSAIDs for over six months underwent combined absorption-permeabili...

BACKGROUND Previous studies have documented the increased cardiovascular risk associated with the use of some nonsteroidal anti-inflammatory drugs (NSAIDs). Despite this, many old NSAIDs are still prescribed worldwide. Most of the studies to date have been focused on specific oral drugs or limited by the number of cases examined. We studied the risk of new acute myocardial infarction (AMI) hosp...

OBJECTIVES To investigate for individual patients who have been using NSAIDs regularly, whether paracetamol is as effective as non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of pain and disability related to osteoarthritis of the hip or knee. METHODS A series of n of 1 trials were conducted in general practices in Amsterdam and the surrounding area. Each patient was his or he...

BACKGROUND Both diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used, in particular among the elderly. The use of NSAIDs may decrease the efficacy of diuretics and induce congestive heart failure (CHF) in patients treated with diuretics. OBJECTIVE To investigate the risk of CHF associated with combined use of diuretics and NSAIDs in patients older than 55 years. METHO...

BACKGROUND/AIM Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drugs (NSAIDs) use are considered to be the most important risk factors having influence on the onset of bleeding gastroduodenal lesions. Whether there is an interaction between H. pylori infection and the use of NSAIDs in the development of peptic ulcer disease is still controversial. The aim of the pre...

Hepatotoxicity is one of the common side effects of nonsteroidal anti-inflammatory drugs (NSAIDs). We investigated the cytotoxicity of 18 acidic NSAIDs (3 salicylic acids, 3 anthranilic acids, 6 arylacetic acids, 6 arylpropionic acids) to freshly isolated rat hepatocytes as assessed by the NSAID-induced leakage of lactate dehydrogenase (LDH) in order to determine structural requirements for the...

The sphincters failure is a part of NSAIDs-toxicity that can be accordingly counteracted. We used a safe stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419), LD1 not achieved, since successful in inflammatory bowel disease trials, and counteracts esophagitis, sphincters failure, gastrointestinal ulcer and skin ulcer, external and internal fistulas in rats, and particularly counte...