Background Lung involvement is the most common extra-articular manifestation. Rheumatoid arthritis related interstitial lung disease (RA-ILD) comprises a heterogeneous group of parenchymal disorders classified by distinct clinical, pathologic, and radiographic features. According to current paradigm, circulating immune complexes aberrant neutrophil extracellular trap formation (NETosis) contrib...

Systems y+ and y+L represent the main routes for arginine transport in mammalian cells. While system y+ activity is needed for the stimulated NO production in rodent alveolar macrophages (AM), no information is yet available about arginine transport in human AM. We study here arginine influx and genes for arginine transporters in AM from bronchoalveolar lavage of normal subjects. These cells ex...

BACKGROUND Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal...

Background Patients with anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis (DM) often develop a rapidly progressive interstitial lung disease (RP-ILD) associated high mortality [1] . Objectives to evaluate clinical features and prognosis of patients anti-MDA5+ DM who developed RP-ILD. Methods Anti-MDA5+ were selected from single center cohort 198 idi...

Background Nintedanib provides a decline in the reduction of forced vital capacity (FVC) patients with progressing lung fibrosis. Objectives To assess demographical, clinical, and radiological characteristics connective tissue diseases (CTDs) associated interstitial disease (ILD), who were under nintedanib treatment. Methods This retrospective observational study was conducted received for fibr...

Background: Interstitial lung disease (ILD) is a severe complication of Rheumatoid Arthritis (RA). Usual interstitial pneumonia (UIP) considered to be more frequent and in RA than non-specific (NSIP). Abatacept (ABA) Rituximab have demonstrated efficacy RA-ILD [1-3]. Objectives: To compare the ABA patients according radiological patterns UIP or NSIP. Methods: From an observational multicenter s...

Interstitial lung disease (ILD) is a very important complication of the idiopathic inflammatory myositides (IIM), with a prevalence of approximately 40 %. Characteristic HRCT changes, most commonly NSIP, together with a restrictive ventilatory defect and an associated decline in DLco support the presence of ILD. The strongest risk factors are the presence of the anti-amino-acyl-tRNA synthetases...

Systemic sclerosis (SSc) is a complex, clinically heterogeneous disease, characterized by extensive vascular alterations, autoantibodies and fibrosis. Interstitial lung disease (ILD) is a frequent cause of death in SSc patients. It is characterized by histopathologically nonspecific interstitial pneumonia (NSIP) or usual interstitial pneumonia (UIP) and occurs to various extents [1,2]. The clin...

Since the seminal report by Averill A. Liebow in 1968 [1] of the first classification of idiopathic interstitial pneumonias (IIPs), consisting of five entities including ‘‘usual or classical interstitial pneumonia’’ (UIP), a secure diagnosis has, until recently, required histopathological evaluation. A histologically based classification might appear paradoxical, as a biopsy is performed in onl...