Cachexia is rare in nude mice bearing human malignant tumors even when the transplanted tumors become as large as the body size of the host. In our series on heterotransplantation of a variety of human malignant tumors into nude mice, a malignant melanoma (SEKI) was found to induce severe body weight loss in the host at the early stage of transplantation. There was no electrolyte disturbance, h...

OBJECTIVE A subcutaneous transplantation tumor model of human HT-29 cells was established in nude mice to study the anticarcinogenic activities and apoptosis-regulatory mechanistic effect of aqueous extract of fermented barley with Lactobacillus plantarum dy-1 (LFBE). METHODS HT-29 cells were transplanted via subcutaneous injection of 1 × 107cells into the right flank of each nude mouse. Then...

Neospora is a cyst-forming coccidian parasite that causes abortions and neuromuscular disorders in a wide variety of mammals. Japanese bovine isolate JPA1 was inoculated intraperitoneally into BALB/c nu/ nu (athymic nude) and BALB/c (congenic wild type) female mice to examine the distribution of parasites and resistance mechanisms to Neospora infection. All the athymic nude mice died within 28 ...

The aim of this research was to confirm the possible synergic effects sasam-Kyeongokgo (SKOG) on anti-tumor activity gefitinib using athymic nude mice bearing human non-small-cell lung squamous cell carcinoma (NSCLC) NCI-H520 line after continuous oral combination treatment provided daily for 35 days within a timeframe 5 min, as developing process novel preventive and therapeutic regimes variou...

Establishing functional circulation in bioengineered tissue after implantation is vital for the delivery of oxygen and nutrients to cells. Native cartilage avascular thrives on diffusion, which turn depends proximity circulation. Here, we investigate whether a gridded three-dimensional (3D) bioprinted construct would allow ingrowth blood vessels thus prove concept vascularization tissue. Twenty...

In this study, we evaluated the role of tumor cell and tumor stroma sensitivity as determinants of radiation-induced tumor growth delay. A DNA double-strand break repair-defective DNA-PKcs(-/-) tumor cell line and its radioresistant DNA-PKcs(+/+)-transfected counterpart were used to initiate tumors in nude and hypersensitive severe combined immunodeficient (SCID) mice. Insertion of the human DN...

Abstract Objectives In our study, we aimed to (1) create a peritoneal metastasis (PM) model in nude mice, administer intraperitoneal chemotherapy using the infusion pump developed this model, and (2) compare efficacy of various drugs at different temperatures. Methods The was established mice CC531 colon carcinoma cell line. Models with were randomized into four groups seven animals each: Group...

In China, the incidence rate and mortality of gastric cancer are in second place among all tumors pathological type is mainly adenocarcinoma. The higher prevalence requires us to do more research. It great significance study antitumor effect hydroxysafflor yellow pigment A aim this was investigate inhibitory on human adenocarcinoma BGC-823 xenograft nude mice. animal model established mice carr...

Liver-derived (LD) murine colon adenocarcinoma MCA-38 cells injected into the ileocolic vein (ICV) of C57BL/6 mice developed distinct hepatic foci within 14-21 days and survived for an average of 19-35 days. In contrast, C57BL/6-nu/nu mice given injections of LD-MCA cells by the same route did not develop hepatic lesions. Furthermore, 111In-labeled LD-MCA-38 tumor cells were rapidly taken up by...

From nude mouse tumors, in which malignantly transformed Bloom's syndrome (BS) B-lymphoblastoid cell lines were successfully transplanted into s.c. tissues, we have detected strong expression of malignant lymphoma (ML)-associated antigen on the cell surface, by using diluted sera of ML patients and indirect immunofluorescence. Even though carcinogen-treated BS B-lymphoblastoid cell lines expres...