In the title compound, [Cd(C(10)H(9)N(4)O(2)S)(2)(C(3)H(7)NO)(2)(H(2)O)]·H(2)O, the Cd(II) ion displays a grossly distorted octa-hedral (or irregular) mer-CdN(3)O(3) coodination polyhdron arising from its coordination by one N,N'-bidentate sulfadiazinate anion, one monodentate sulfadiazinate anion, two O-bonded dimethyl-formamide molecules and one water mol-ecule. A short Cd⋯N contact [2.890 (3...

The alkaline perhydrolysis of the nerve agent O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) was investigated by studying the ion-molecule reactions of HOO(-) with O,S-dimethyl methylphosphonothioate in a modified linear ion-trap mass spectrometer. In addition to simple proton transfer, two other abundant product ions are observed at m/z 125 and 109 corresponding to the S-met...

s e l e c t i o n o f a p p r o p r i a t e g r o u n d m o t i o n i s a k e y e l e m e n t w i t h i n a n y s e i s m i c a s s e s s m e n t o f s t r u c t u r e s. m a n y m e t h o d o l o g i e s h a v e b e e n d e v e l o p e d i n o r d e r t o s e l e c t a n d s c a l e g r o u n d m o t i o n r e c o r d s f o r t h e p u r p o s e o f r e s p o n s e h i s t o r y a n a l y s i ...

A palladium-catalyzed annulation of ortho-vinylanilines with dimethyl sulfoxide was developed to access 4-aryl quinolines in moderate to good yields. Activated by 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO), DMSO served as a "[double bond, length as m-dash]CH-" fragment in this transformation. It represents a facile pathway leading to 4-aryl quinolines.

o-Alkynylarenenitriles when heated with Pd(OAc)2/H2O/(±)-CSA in DMSO undergo simultaneous alkyne oxidation and nitrile hydration to give 3-aryl-3-hydroxy-2,3-dihydroazanaphthoquinones. Upon treatment with (±)-CSA, these compounds form 3-arylazanaphthoquinones in situ, which add to electron-rich aromatics and terminal alkene/alkyne to afford 3,3-disubstituted-2,3-dihydroazanaphthoquinones.

For the preparation of a carbocyclic nitrogen analogue of S-adenosylmethionine (carba-AdoazaMet, 4), a practical synthesis of (-)-aristeromycin (7) has been developed using variations of literature procedures. This approach called for a stereospecific synthesis of (3aR,6aR)-2,2-dimethyl-3a,6a-dihydrocyclopenta[1,3]dioxol-4-one ((4R, 5R)-4,5-O-isopropylidene-2-cyclopentenone) (8), which was achi...

In the title compound, C(14)H(14)ClNO(2)S, the angle between the sulfonyl and aniline benzene rings is 65.5 (1)°. The crystal structure features inversion dimers linked by pairs of N-H⋯O hydrogen bonds. The dimethyl-phenyl ring is disordered over two different orientations approximately related by a 180° rotation about the C-N bond, with occupancies of 0.643 (6) and 0.357 (6).

The asymmetric unit of the title salt, CH(6)N(3) (+)·C(2)H(8)N(+)·C(10)H(6)O(6)S(2) (2-), consists of one dimethyl-ammonium cation, one guanidinium cation, and two half naphthalene-1,5-disulfonate anions, which lie on inversion centers. N-H⋯O hydrogen bonds link the cations and anions into layers parallel to the ab plane. The layers have a sandwich-like structure, with the sulfonate groups and ...

The asymmetric unit of the title compound {systematic name: (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methyl-hept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodeca-hydro-1H-cyclo-penta-[a]phenanthren-3-yl p-toluene-sulfonate}, C(36)H(54)O(3)S, comprises two independent mol-ecules that differ significantly in terms of the relative orientations of the peripheral groups; the ...

a l t h o u g h m o s t c o m p a n i e s s p e n d l e s s o n p r o d u c t d e s i g n, e x p e r i e n c e s h o w s t h a t, t h e s e c o m p a n i e s h a v e t o p a y h i g h e r c o s t s d u e t o p r o d u c t i o n p r o b l e m s o r l o s s o f m a r k e t. l i t e r a t u r e s t u d i e s s h o w t h a t t h e d e s i g n f o r s i x s i g m a i s a p o w e r f u l a p p r o a ...