We have reported a 27% overall anti-tumor response using i.p. immunotherapy of advanced ovarian carcinoma with autologous, ex vivo expanded, T lymphocytes re-targeted with bi-specific monoclonal antibody OC/TR, combined with soluble OC/TR and low-dose recombinant interleukin-2 (IL-2). This treatment had no effect on extraperitoneal disease. Therefore we studied in 13 patients whether this immun...

Organochlorine contaminants (OCs) were determined in liver and fat of seven species of seabirds (Alle alle, Uria lomvia, Cepphus grylle, Rissa tridactyla, Pagophila eburnea, Larus hyperboreus, and Fulmaris glacialis) collected in May/June 1998 from the Northwater Polynya in northern Baffin Bay. OC concentrations ranged over an order of magnitude between seabird species and OC groups, with PCBs ...

We conducted 2 studies to determine the effect of vitamin D-fortified cheese on vitamin D status and the bioavailability of vitamin D in cheese. The first study was designed to determine the effect of 2 mo of daily consumption of vitamin D3-fortified (600 IU/d) process cheese on serum 25-hydroxyvitamin D (25-OHD), parathyroid hormone (PTH), and osteocalcin (OC) concentrations among 100 older (>...

Chmiel, H. E. 2015. The role of sediments in the carbon cycle of boreal lakes. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1279. 42 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9318-9. Inland waters are active sites of carbon (C) processing and emitters of carbon dioxide (CO2) and methane (CH4) to the atmosphere. In the bor...

BACKGROUND In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs). METHODS We first used a computational target prediction analysis to identify 6 candidate miRNAs that bind to the 3'-untran...

As the eighth most common malignant tumour worldwide, oesophageal cancer (OC) is often diagnosed during the metastasis of its advanced stage. Interleukin (IL)-23 is an immunomodulatory cytokine that has recently been identified as a cancer-associated factor. However, the role of IL-23 in the evolution of OC remains unclear. In the present study, we found that IL-23 was significantly expressed i...

Sharp wave-associated synchronized inputs from the piriform cortex activate olfactory tubercle 1 neurons during slow-wave sleep 2 3 Kimiya Narikiyo Abstract 18 During slow-wave sleep, anterior piriform cortex neurons show highly synchronized discharges that 19 accompany olfactory cortex sharp waves (OC-SPWs). The OC-SPW-related synchronized activity of 20 anterior piriform cortex neurons travel...

An intensive observation of organic carbon (OC) and elemental carbon (EC) in PM10 and gaseous materials (SO2, CO, and O3) was conducted continuously to assess the characteristics of wintertime carbonaceous aerosols in an urban area of Beijing, China. Results showed that the averaged total carbon (TC) and PM10 concentrations in observation period are 30.2 +/- 120.4 and 172.6 +/- 198.3 microg/m3,...

BACKGROUND Current American Cancer Society recommendations for colon cancer screening include optical colonoscopy every 10 years or computed tomography colonography (CTC) every 5 years. Bowel preparation (BP) is currently required for both screening modalities. PURPOSE To compare ACRIN 6664: the National CT Colonography Trial (NCTCT) participant experiences with CTC and optical colonoscopy (O...

Efficiently obtaining full-length cDNA for a target gene is the key step for functional studies and probing genetic variations. However, almost all sequenced domestic animal genomes are not 'finished'. Many functionally important genes are located in these gapped regions. It can be difficult to obtain full-length cDNA for which only partial amino acid/EST sequences exist. In this study we repor...