Dear Editor-in-Chief   Lesional histopathological features in pityriasis rosea (PR) are non-specific (1).  Our aim here is to investigate whether a histopathological take-off sign (TOS) is associated with PR.

This report describes the case of a 76 year old man who suffered from febrile ulceronecrotic Mucha–Habermann disease (FUMHD). Despite this patient’s typical clinical and histological findings, the fulminating course led to death. Polymerase chain reaction (PCR) analysis of the skin lesions showed that the infiltrating cells were monoclonal in origin and were from an aberrant clone. FUMHD is a v...

A 10-year-old boy presented with a persistent rash that began several months earlier as recurrent crops of papules and a few vesicles with crusting. Varicella was initially diagnosed, and the patient was treated unsuccessfully with over-the-counter drying lotions. The patient denied systemic symptoms and pruritus and was in his usual state of health otherwise. Review of systems, family history,...

Multiple bioengineered agents has been recently developed to attack other parts of the immune/inflammatory system, achieving therapeutic implications for dermatologic diseases. On the other side, each new therapy has the potential for adverse cutaneous reactions. We present herein the first two cases of Gibert's pityriasis rosea occurring during etanercept therapy and discuss possible links bet...