UNLABELLED The advent of amniotic membrane (AM) and limbal stem cell grafts have transformed the treatment of diseases resulting in ocular surface failure. The current success may be attributed to cryopreservation of human AM, which retains its properties and renders the amniotic epithelial cells nonviable and thus nonimmunogenic. Its unique properties have prompted its application in a large n...

1. Abstract 2. Introduction 3. Overview of Transforming growth factor β (TGFβ) signal transduction 4. Central role of TGFβ in fibrogenic reaction 5. Generation of myofibroblasts by TGFβ 6. Epithelial-mesenchymal transition (EMT) 7. Outline of ocular fibrotic disorders 8. Fibrosis/scarring in ocular surface, i. e., cornea and conjunctiva 9. Strategies to prevent excess fibrogenic reaction in ocu...

The chronic glaucoma with open angle is the second leading cause of blindness in the world. Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. Poor bioavailability of drugs from ocular dosage form is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium....

The ocular surface-a continuous epithelial surface with regional specializations including the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian glands connected by the overlying tear film-plays a central role in vision. Molecular and cellular events involved in embryonic development, postnatal maturation, and maintenance of the ocular surface are precisely ...

About 90% of the world's population is exposed to air pollutants beyond limits World Health Organization (WHO) recommended. Due regular contact atmospheric with cornea, tear film, and conjunctiva, present in have direct access these ocular structures. Exposure different parts eye polluted results burning redness eye, disorders, several other problems. Several studies shown drastic impact pollut...

Introduction: Pathological myopia (PM) is defined as the presence of structural changes due to axial elongation in eyes with high myopia. Numerous vision-threatening conditions are known be more prevalent pathological including retinal detachment, myopic retinoschisis, macular holes, choroidal neovascularization, and chorioretinal atrophy. These often lead progressive loss vision. Present study...