OBJECTIVES/HYPOTHESIS Nasal irrigations are commonly employed to promote nasal hygiene in the treatment of various sinonasal conditions. Few studies have evaluated how the ionic composition of irrigation solutions affects olfactory performance. The purpose of this study was to determine the dose responsiveness of human olfactory thresholds for each of the following ions: potassium, sodium, and ...

BACKGROUND The aim of the study was to investigate odor identification performance in patients one year after hospital admittance due to stroke. Predictors for olfactory dysfunction were investigated as well as self-reported olfactory function and pleasantness of olfactory items. METHODS A 1-year prospective study was performed. Stroke location, classification and comorbidities were registere...

olfactory neuroepithelium.5,6 Douek et aP have described the histopathologic changes in the olfactory neuroepithelium in several types of anosmia. Incorrect or incomplete contact of the olfactory receptor neurons with the CNS was detected in a patient with congenital anosmia. Severe destruction of the olfactory neuroepithelium has resulted from infection with the influenza virus7 and herpes sim...

BACKGROUND In Alzheimer's disease (AD) the olfactory system, including the olfactory bulb, a limbic paleocortex is severely damaged. The occurrence of early olfactory deficits and the presence of senile plaques and neurofibrillary tangles in olfactory bulb were reported previously by a few authors. The goal of the present study was to analyze the occurrence of AD-type degenerative changes in th...

Olfactory systems in organisms ranging from invertebrates to mammals distinguish between odors using an array of olfactory neurons that express different olfactory receptors—usually just one receptor in a given neuron. Since an organism’s genome can encode hundreds of olfactory receptors, researchers have struggled to understand how a single olfactory neuron decides which receptor to express. I...

While there is evidence that feedback projections from cortical and neuromodulatory structures to the olfactory bulb are crucial for maintaining the oscillatory dynamics of olfactory bulb processing, it is not clear how changes in dynamics are related to odor perception. Using electrical lesions of the olfactory peduncle, sparing output from the olfactory bulb while decreasing feedback inputs t...

Perceptual learning is required for olfactory function to adapt appropriately to changing odor environments. We here show that newborn neurons in the olfactory bulb are not only involved in, but necessary for, olfactory perceptual learning. First, the discrimination of perceptually similar odorants improves in mice after repeated exposure to the odorants. Second, this improved discrimination is...

treatment of spinal cord injury by exogenous cells has brought both successful and unsuccessful results. olfactory ensheathing cells and schwann cells have been widely used for transplantation purposes. in this study, we investigated the effects of these cells on contused spinal cord by introducing cells into subarachnoid space. fifty thousand schwann cells or olfactory ensheathing cells or a m...

Esthesioneuroblastoma(Olfactory neuroblastoma) is a rare malignant neoplasm arising from basal cells within the olfactory epithelium. Its clinnical course is unpredictable with variable correlation between microscopic features and biological behaviour.[1] We report a very indolent case of olfactory neuroblastoma presented only with nasal obstruction due to unilateral mass at the anterolateral a...

Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form the odor percept. However, mechanisms governing the integration of sensory info...