A total of 702 sera, 81 cerebrospinal fluids and 131 urine specimens were studied for the evaluation of a high resolution electrophoresis system, as well as the usefulness of electrophoresis in general. Abnormal changes were found in 41.6 percent of the serum specimens. Meaningful changes of individual fractions were most frequently encountered in the gamma frac­ tion. In six recognized electro...

A 20-year-old man presented with vertigo followed by hourly episodes of dysarthria and incoordination lasting 5–20 seconds (video 1). Neurologic examination was normal between episodes. The only brain/spine MRI lesion in the right superior cerebellar peduncle (figure, A). CSF analysis revealed elevated white blood cells (6/?L [normal, 0–5]) oligoclonal bands (?4). Paroxysmal dysarthria–ataxia a...

Abstract Multiple sclerosis (MS) patients with immunoglobulin gamma (IgG) oligoclonal bands (OCB) in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features compared to those without. In this study, we aimed determine whether CSF-OCB status is associated long-term disability outcomes. We used Swedish MS register data on clinically definite known OCB status. Date ...

We investigated 16 lymphoid proliferations occurring in the ocular adnexa, salivary glands, breast, and thyroid gland and satisfying the histopathologic and immunophenotypic criteria of benign lymphoid hyperplasia for the presence of clonal rearrangements of the antigen receptor, c-myc, bcl-1, and bcl-2 genes and Epstein-Barr virus (EBV) DNA sequences. Each of these 16 extranodal, noncutaneous ...

To the Editor: In .95% of patients suffering from clinically unambiguous multiple sclerosis (MS), oligoclonal IgG can be detected in cerebrospinal fluid (CSF) (1, 2). Isoelectric focusing is the most sensitive method for detecting oligoclonal bands (OCBs) (1 ), whereas agarose gel electrophoresis is reported to detect OCBs in ;80% of cases (2 ). A commercial electrophoresis unit (Beckman Instru...

Patients with the B-cell malignancy hairy cell leukemia (HCL) exhibit a skewed T-cell repertoire with oligoclonal expression or absence of many members of the T-cell receptor (TCR) BV gene families. To evaluate whether interferon-alpha (IFN-alpha) therapy would not only restore normal hematopoiesis, but also the abnormal T-cell repertoire, we studied T lymphocytes from a cohort of HCL patients ...

Multiple sclerosis (MS)' is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) that has been postulated to be a T cellmediated autoimmune disorder (1, 2) . At sites of active demyelination, the majority of infiltrating cells are T cells and macrophages, with smaller numbers of B cells (1) . In the cerebrospinal fluid (CSF), >85% of cells are T lymphocytes (3) . T...