objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...

The association of pulmonary hypoplasia with bilateral renal agenesis is well recognised. It is important, however, for clinicians to be aware that pulmonary hypoplasia does occur with other congenital renal anomalies and worsens the prognosis. The aims of this review are to highlight other kidney and associated pulmonary abnormalities, describe the mechanisms of abnormal lung growth associated...