The aim of this study was to assess the anti-tumor effect of photodynamic therapy (PDT) using a novel bacteriochlorophyll derivative, palladium-bacteriopheophorbide (TOOKAD) on tumor growth, perfusion and oxygenation. Rat DS-sarcomas were treated with either TOOKAD-PDT (2 mg/kg, i.v., immediate illumination) or one of the control treatments (sham-treatment, illumination without photosensitizer,...

BACKGROUND & OBJECTIVES Genetic polymorphism of CYP2C19 is known to occur with a frequency of 12 per cent in north Indian population. But no study correlated CYP2C19 genetic polymorphism with eradication of Helicobacter pylori in north Indian gastritis patients positive for H. pylori and hence this study. METHODS Ninety one consecutive patients positive for H. pylori fulfilling the study crit...

Photodynamic therapy (PDT) has become an attractive option used in tumor treatment via its direct tumoricidal activities or its immune-boosting activities. On the other hand, heat shock protein 70 has been found to be largely associated with the establishment of anti-tumor activities offered by hyperthermia treated tumor cells. In the present study, we found that injection of tumor-bearing mice...

We investigated the effect of a major physiologic event, phagocytosis. on the ability of human neutrophils (PMN) to bind the synthetic chemotactic peptide, 3H-formyl-methionyl-leucyl-phenylalanine (3H-FMLP). We found that both latex and opsonized zymosan (OPZ) particles caused dosedependent suppression of 3H-FMLP binding and abolition of 3H-FMLP binding with concentrations of OPZ greater than 2...

Polymorphonuclear leukocytes (PMNs) engaged in phagocytosis produce reactive oxygen species (ROS), such as those that occur in an activated NADPH oxidase reaction, to eliminate ingested microorganisms. The translocation of NADPH oxidase components to produce antimicrobial free radicals from the vesicles to the phagosomes may be important. Hydrogen peroxide (H2O2) derived from O2- has been obser...

Despite evidence suggesting that protein kinase C (PKC) isoforms are important in phagocytosis by Fcgamma receptors, the mechanisms by which the substrates of these kinases act are largely unknown. We have investigated the role of one PKC substrate, pleckstrin, in cells of the monocyte/macrophage lineage. Pleckstrin expression in mouse macrophages was induced severalfold in response to bacteria...

In our contribution, we relate the development of a richly annotated corpus and a computational valency lexicon. Our valency lexicon, called PDT-Vallex (Hajič et al., 2003) has been created as a “byproduct” of the annotation of the Prague Dependency Treebank (PDT) but it became an important resource for further linguistic research as well as for computational processing of the Czech language. W...

Platelet-activating factor (PAF) is a potent chemoattractant for human eosinophils and neutrophils and causes eosinophil and neutrophil recruitment into animal airways. Since eosinophils and eosinophil cationic proteins are thought to play an important role in the pathophysiology of asthma, we have examined the hypothesis that PAF may also stimulate eosinophil cationic protein (ECP) release fro...

Photodynamic therapy (PDT) is a well-documented therapy for non-melanoma skin cancer, which has excellent therapeutic effect and cosmetic outcome combined with minimal invasiveness (1). PDT is easy to use in treatment of large areas, and thus is particularly suitable for use in areas of field cancerization with several to many actinic keratoses (AK) (1). However, a major disadvantage of PDT is ...

Developing drugs to treat gastric acid related illnesses such as ulcers and acid reflux disease is the leading focus of pharmaceutical companies. In fact, expenditure for treating these disorders is highest among all illnesses in the US. Over the last few decades, a class of drugs known as a proton pump inhibitors (PPIs) appeared on the market and are highly effective at abating gastric illness...