Previous results from our laboratory indicated two major genetic components of spontaneously hypertensive rat (SHR) hypertension, an autosomal component and a Y chromosome component. Two new substrains, SHR/a and SHR/y, were developed using a series of backcrosses to isolate each of these components. The SHR/a substrain has the autosomal loci and X chromosome from the SHR strain and the Y chrom...

Abstract Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed investigate comparative effects high fat, sucrose and salt-induced IR fatty acid transporter (FATP) glucose (GLUT4) in rats. Results Rats fed with salt diets developed impaired tolerance ( p > 0.05) hyperinsulinemia < ...

the present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic datura stramonium (ds) seed extract as a rich source of alkaloid substances. male nmri rats were divided into control and treatment groups. the treatment rats received different doses of the ds seed extract, which was prepared from alcoholic smashed s...

background: peripheral nerves may be damaged during an injury and its current standard treatment is using an autologous nerve. objectives: the purpose of this experimental study is to evaluate and compare the histological results of nerve regeneration after using the eggshell membrane (esm) guidance channel with autograft. materials and methods: thirty adult male rats were divided into three ex...

background: accumulation of triglycerides in the liver i.e. steatosis, is a well-known side-effect of tamoxifen administration to patients suffering from breast cancer. cichoriumintybus (chicory) is a plant used as traditional medicine for curing liver disorders. in this study, the effects of extract prepared from chicory roots on tamoxifen-induced liver steatosis and related biochemical factor...

objective(s):   this study aimed to address the gold nanoparticle(gnp)-dose and exposure duration effect on the kidney function of rats: in vivo.   materials and methods: a total of 32 healthy male wistar rats were used in this study. animals were randomly divided into groups, three gnp-treated groups and control group. group 1, 2 and 3 received. /5 cc of solution containing 5, 10,100 ppm au vi...

objective: curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. the present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. materials and methods: in urethane-anesthetized rats, epileptiform activity was induced by intraco...

objective: the present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of rosa canina (r. canina) against carbon tetrachloride (ccl4)-induced hepatotoxicity in rats. methods: male wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (ccl4), r. canina 250, 500, and 750 mg/kg + ccl4 and r. canina ...

objective: crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. in the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. materials and methods: subcutaneous injection of a diluted formal...